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0224U033338,
(0124U002194)
,
A two-vector method of research and optimization of approaches in the diagnosis and therapy of traumatic conditions of the skeletal muscles of the limbs.
Розробка та апробація способів оцінки функціонального стану скелетних м'язів.
Zavodovskyi Danylo O., Кандидат біологічних наук
25-12-2024
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
The purpose of the project is the development and experimental testing of a combined method of researching traumatic conditions of the skeletal muscles of the limbs, analysis and comparison of the effectiveness of therapeutic approaches, on animal model objects at the first stage of evaluation, by combining tensometry with recording of EMG and M-responses, and at the second stage the proposed experimental design of testing on a robotic research system for the implementation of imposed movement programs will allow to evaluate pathological conditions and their dynamics by means of functional diagnosis of the upper limbs based on the change of marker features of the temporal structure of EMG signals during the execution of movement commands in involved people with orthopedic and/or neuropathological problems at various stages of their treatment.
Approaches for diversification of the mechanograms of rat limb muscles in the post-amputation period, under ischemic preconditioning and intact ones are proposed. Specialized program codes were created to accelerate the analysis of the functional state of skeletal muscles by automating the research section between the recording of mechanograms and the stage of data interpretation. OriginLab software was used in combination with the Python language interpreter integrated into it, which allowed the use of specialized libraries with open source code. The possibility of writing adaptive programs for assessing the state of motor function was demonstrated on a robotic-mechatronic device. It was shown that the hysteresis properties of muscles significantly affect the formation and execution of a motor task by the central nervous system on muscle groups, which should be taken into account when searching for mechanokinetic and electromyographic markers of sensitivity to pathological effects on limb muscles.
Zavodovskyi Danylo O.
Lehedza Oleksii V.
2024-12-25
Updated: 2025-12-26
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