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Information × Registration Number 0224U033339, (0123U103182) , R & D reports Title Molecular mechanisms of development of insulin resistance and restructuring of energy metabolism in metabolic syndrome popup.stage_title Дослідження участі адипокінів та білків-регуляторів метаболізму у розвитку інсулінорезистентності, змінах метаболізму та порушенні ультраструктури міокарда при моделюванні метаболічного синдрому і гіпоксичних впливах Head Kozlovska Mariia H., аспірант Registration Date 25-12-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 To establish the role of adipokines (chemerin, apelin, leptin) and PGC-1 in the development of insulin resistance and restructuring of the energy metabolism of the myocardium in metabolic disorders and hypoxic effects. popup.description2  This work describes the role of adipokines and the metabolic regulator protein PGC-1 in the development of insulin resistance, metabolic changes, and myocardial ultrastructure disorders. When reproducing insulin resistance, an increase in leptin receptor expression was found in the myocardium of Wistar rats, but without a significant increase in the levels of the adipokines leptin, chemerin, and apelin, as observed in experimental type 2 diabetes. PGC-1 protein expression was higher in myocardial hypertrophy. Insulin resistance contributed to an increase in its level, and when combined with hypoxic preconditioning, a significant increase in PGC-1 levels was noted in the right ventricle of the heart. Morphometric studies revealed that insulin resistance is accompanied by an increase in myocardium myoprotection. At the same time, hypoxic preconditioning partially loses its cardioprotective and mitoprotective effects in insulin resistance. In hypertrophied myocardium, better structural protection of mitochondria was found, but with increased myofibril damage and loss of the protective effect of preconditioning. Product Description popup.authors Zavhorodnyi Mykola O. Kozlovska Mariia H. popup.nrat_date 2024-12-25 Close