Registration Number
0224U033358,
(0122U202075)
, R & D reports
Title
Determination of adverse prognostic factors and effectiveness of specific therapy, detection of morbidity and mortality associated with covid-19 and martial law conditions in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH)
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Визначення факторів несприятливого прогнозу та ефективності специфічної терапії, виявлення захворюваності та смертності, асоційованої із covid-19 та умовами воєнного стану у пацієнтів із легеневою артеріальною гіпертензією (ЛАГ) та хронічною тромбоемболічною легеневою гіпертензією (ХТЕЛГ)
Head
Sirenko Yurii M., д.мед.н.
Registration Date
25-12-2024
Organization
State Institution "National Scientific Center "Institute of Cardiology, clinical and regenerative medicine named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine
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Improvement of stratification of the risk of an adverse course and objectification of the criteria for the effectiveness of specific therapy in patients with pulmonary hypertension based on non-invasive assessment of the state of the left and right ventricle and elasticity indicators of systemic arteries and assessment of survival and progression of the disease in the conditions of COVID-19, taking into account the state of war.
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The incidence of COVID-19 in patients with PAH and CTEPH was higher (10.2%) than in the general Ukrainian population, but it did not affect the mortality of patients with pulmonary hypertension. The introduction of martial law did not significantly affect the organization of inpatient and outpatient specialized care for patients with PAH and CTEPH. Hemodynamic thresholds associated with an unfavorable prognosis were determined and it was substantiated that the use of additional catheterization indicators, namely the ratio of the right ventricular stroke work index/left ventricular stroke work index <0.55 and the ratio of the right ventricular pumping coefficient/left ventricular pumping coefficient <0.35, allow for more accurate risk stratification of patients with idiopathic PAH. The most informative echocardiographic parameters that were significantly correlated with prognostic hemodynamic parameters determined during right heart catheterization were TAPSE, longitudinal strain of the right ventricular free wall, the ratio of TAPSE/calculated systolic pressure in the pulmonary artery, and the ratio of longitudinal strain of the right ventricular free wall/systolic pressure in the pulmonary artery.
For the first time in Ukraine, the incidence of COVID-19 in patients with pulmonary hypertension was studied and its impact on mortality was assessed. The most informative hemodynamic parameters obtained during right heart catheterization and echocardiographic parameters for prognosis were identified. The need for a comprehensive assessment of the condition of both the right and left ventricles was shown. Based on correlation analysis, echocardiographic parameters were determined that demonstrate a high degree of correlation with the main prognostically significant hemodynamic parameters obtained during right heart catheterization and that can be used for dynamic monitoring of patients with idiopathic PAH. The impact of martial law on of care in PAH patients.
Product Description
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Botsiuk Yurii A.
Kushnir Svitlana M.
Радченко Ганна Дмитрівна
Rekovets Oksana L.
Torbas Olena O.
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2024-12-25
