Registration Number
0224U033428,
(0123U103303)
, R & D reports
Title
Creation and characterization of the safety and biological activity of nanosized magnesium oxide compounds.
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Дослідження токсікологічних характеристик та фармакологічних властивостей отриманих нанорозмірних оксидних сполук магнію.
Head
Valivodz Iryna P., Кандидат біологічних наук
Registration Date
27-12-2024
Organization
Physico-Chemical Institute O. Bogatsky National Academy of Sciences of Ukraine
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The purpose of the work is to obtain samples of nanosized magnesium compounds and study the effect of their size on biological properties (anticonvulsant, analgesic, anti-inflammatory), as well as theoretical substantiation and prediction of the activity of magnesium compounds using QSAR modeling. In the course of the work, nanosized oxide compounds of magnesium will be synthesized, their physico-chemical and physical indicators will be determined, the main physical and biological properties will be analyzed and predicted by the methods of computer modeling and QSAR analysis, the toxicity and tolerability will be characterized, and the biologically active effect (analgesic and anticonvulsant). The topic of the work is relevant both from the point of view of fundamental research (methods for obtaining nanoscale magnesium oxide derivatives will be developed, methods of QSAR analysis and prediction of the physico-chemical and biological properties of these compounds will be developed), and applied research (in vivo conditions, the toxicological characteristics of the obtained compounds will be established , a study of pharmacological effectiveness was conducted, the potential possibility of their use as analgesic or anticonvulsant compounds was determined).
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Nanometer-sized magnesium oxide compounds have unique physicochemical properties that are useful in medicine, particularly for drug delivery, tissue engineering, and diagnostics. However, their safety and biological activity require further investigation. Magnesium nanoparticles exhibit high surface activity, which facilitates their permeability through tissue membranes and may reduce the negative effects of medications. Nevertheless, experimental studies on the use of nanomagnesium in medicine are insufficient, and studies on its toxicity are necessary for safe application.
The aim of this study is to develop methods for synthesizing nanometer-sized magnesium oxide compounds and analyze their physicochemical and pharmacological properties. The synthesis was performed using thermal treatment of Mg2(OH)2CO3·4H2O at 800°C in different environments. Infrared spectroscopy was used to investigate the decomposition of magnesium hydroxocarbonate in various media. The biological activity was analyzed using the 1D-QSAR/QSPR approach, which establishes the relationship between the properties of compounds and their activity. The QSAR model was built using the partial least squares (PLS) method and validated by randomization.
Biological experiments were conducted on animals, evaluating seizure activity and behavioral responses in mice after administering MgSO4. Magnesium administration increased the time spent in the central zone and reduced the time of immobility, indicating a calming effect. The 1D-QSAR model predicted the biological activity of MgO nanoparticles, showing that the metal ion charge and the nature of the oxide significantly influence cytotoxicity.
The study also demonstrated that daily administration of MgSO4 at a dose of 200 mg/kg did not cause significant changes, but a single administration at 400 mg/kg reduced the toxicity of corasol. The combination of magnesium with memantine also improved the psycho-emotional state of mice.
Product Description
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Babenko Anton V.
Valivodz Iryna P.
Stelmakh Serhii I.
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2024-12-27
