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Information × Registration Number 0224U033464, (0121U111551) , R & D reports Title To study the features of the course of non-alcoholic fatty liver disease in patients with an immune response to SARS-CoV2 and to substantiate new approaches to diagnostic and treatment tactics popup.stage_title Вивчити особливості перебігу неалкогольної жирової хвороби печінки у хворих з імунною відповіддю до SARS-CоV2 та обґрунтувати нові підходи до діагностично-лікувальної тактики Head Stepanov Yurii M., д.мед.н. Registration Date 28-12-2024 Organization State institution institute of gastroenterology of nams of Ukraine popup.description1 On the basis of the complex analysis of interrelations of clinical-laboratory-instrumental indicators to define features of a course of nonalcoholic fatty liver disease at patients with immune response to SARS-CoV2 and to substantiate tactics of conducting this category of patients popup.description2  The purpose of the study is to determine, based on a comprehensive analysis of the relationships between clinical, laboratory and instrumental indicators, the features of the course of non-alcoholic fatty liver disease in patients with an immune response to SARS-CoV2 and to substantiate the tactics of managing this category of patients. Research methods: clinical, instrumental, immunological, immunoenzymatic, microbiological, statistical. The features of the course of non-alcoholic fatty liver disease in patients with an immune response to SARS-CoV2 were determined, which were manifested by the presence of cholestasis and cytolysis syndromes, an increase in the level of coagulation factor II (prothrombin), a significant decrease in T-lymphocytes, an increase in the level of pro-inflammatory cytokines (IL-6 and TNF-α), which contributed to an increase in the stiffness of the liver parenchyma. It was shown that bacterial overgrowth syndrome was observed in 43.5% of patients, the presence of profound changes in the colonic microflora was observed in 89.5% of patients, a decrease in the concentration of butyric acid, an increase in acetic and propionic acids in feces. It was found that SARS-CoV-2 changes the metabolism of free fatty acids in blood serum, which leads to an increase in the atherogenic coefficient. Product Description popup.authors Bocharov Hennadii I. Didenko Volodymyr I. Klenina Inna A. Melanich Svitlana L. Petishko Oksana P. Oksana M. Tatarchuk Yahmur Victoriia B. popup.nrat_date 2024-12-28 Close