Registration Number
0224U033464,
(0121U111551)
, R & D reports
Title
To study the features of the course of non-alcoholic fatty liver disease in patients with an immune response to SARS-CoV2 and to substantiate new approaches to diagnostic and treatment tactics
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Вивчити особливості перебігу неалкогольної жирової хвороби печінки у хворих з імунною відповіддю до SARS-CоV2 та обґрунтувати нові підходи до діагностично-лікувальної тактики
Head
Stepanov Yurii M., д.мед.н.
Registration Date
28-12-2024
Organization
State institution institute of gastroenterology of nams of Ukraine
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On the basis of the complex analysis of interrelations of clinical-laboratory-instrumental indicators to define features of a course of nonalcoholic fatty liver disease at patients with immune response to SARS-CoV2 and to substantiate tactics of conducting this category of patients
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The purpose of the study is to determine, based on a comprehensive analysis of the relationships between clinical, laboratory and instrumental indicators, the features of the course of non-alcoholic fatty liver disease in patients with an immune response to SARS-CoV2 and to substantiate the tactics of managing this category of patients.
Research methods: clinical, instrumental, immunological, immunoenzymatic, microbiological, statistical.
The features of the course of non-alcoholic fatty liver disease in patients with an immune response to SARS-CoV2 were determined, which were manifested by the presence of cholestasis and cytolysis syndromes, an increase in the level of coagulation factor II (prothrombin), a significant decrease in T-lymphocytes, an increase in the level of pro-inflammatory cytokines (IL-6 and TNF-α), which contributed to an increase in the stiffness of the liver parenchyma. It was shown that bacterial overgrowth syndrome was observed in 43.5% of patients, the presence of profound changes in the colonic microflora was observed in 89.5% of patients, a decrease in the concentration of butyric acid, an increase in acetic and propionic acids in feces. It was found that SARS-CoV-2 changes the metabolism of free fatty acids in blood serum, which leads to an increase in the atherogenic coefficient.
Product Description
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Bocharov Hennadii I.
Didenko Volodymyr I.
Klenina Inna A.
Melanich Svitlana L.
Petishko Oksana P.
Oksana M. Tatarchuk
Yahmur Victoriia B.
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2024-12-28
