Registration Number
0225U000016,
(0122U000443)
, R & D reports
Title
Development of new approaches to the synthesis of fluorine-containing polyfunctionalized natural compounds and their structural analogues
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Синтез та вивчення фізико-хімічних властивостей флуоровмісних аналогів амінокислот, проліну та γ-аміномасляної кислоти, амінів, циклічної так і ациклічної природи, аналогів природних біоактивних сполук
Head
Ihor I. Herus, д.х.н.
Registration Date
02-01-2025
Organization
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
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Development of methods for the synthesis of new and known promising bioactive compounds, in particular new analogues of natural substances with potential biological properties, such as gamma-aminobutyric and glutamic acids, amines, alkaloids and other analogues of natural compounds containing fluorine atoms or fluorine-containing groups.
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A method has been developed for obtaining a previously unknown 1-azido-1,1,2,2-tetrafluoroethane, which undergoes a [3+2] cycloaddition reaction with terminal alkynes, giving 4-substituted N-tetrafluoroethyl-1,2,3-triazoles.
A new method for the synthesis of polyfluoroalkyl-containing pyrroles using available α,β-unsaturated polyfluoroalkyl ketones and natural α-amino acids has been developed and their chemical properties have been investigated: electrophilic reactions (halogenation and acylation) and reduction of the pyrrole ring to obtain fluoroalkyl-containing pyrrolizidines.
Methods for the synthesis of functionalized derivatives of difluorocyclopentane and difluorobicyclo[3.1.0]hexane starting from 3,3-difluorocyclopentene have been investigated.
An effective method for the synthesis of compounds containing the (trifluoromethyl)spiro[3.3]heptane fragment of trifluoromethyl-containing cyclobutanes has been developed.
7-(trifluoromethyl)-2,3-dihydro-1H-pyrrolizines and bicyclic trifluoromethyl-containing pyrroles were found to be effective synthetic antimicrobial agents with a broad spectrum of antimicrobial activity, including against multidrug-resistant Gram-positive and Gram-negative bacterial pathogens.
Product Description
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Vdovenko Serhii I.
Dolovaniuk Violetta H.
Klipkov Аnton А.
Kulyk Iryna B.
Lohvynenko Ivan H.
Rybakova Antonina V.
Romanenko Vladyslav D.
Ruchko Yevheniia V.
Fedorenko Оlena А.
Feskov Іlia О.
Hilchevskyi Oleksandr М.
Shaitanova Olena M.
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2025-01-02
