Registration Number
0225U000404,
(0123U103247)
, R & D reports
Title
Correction of violations of osteogenesis processes in the treatment and prevention of complications of dental diseases in wartime
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1. Вивчення генетичних детермінант порушень процесів остеогенезу в контексті лікування та профілактики ускладнень стоматологічних захворювань у воєнний час
Head
Dienha Oksana V., Доктор медичних наук
Registration Date
10-01-2025
Organization
State Establishment «Institute of Stomatology and Maxillofacial Surgery National Academy of Medical Sciences of Ukraine"
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Development and introduction into clinical practice of methods of diagnosis, prevention and treatment of osteogenesis disorders during dental intervention in patients in wartime
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The object of the study is genetic determinants that lead to the violation of osteogenesis processes in the conditions of dental pathology and associated complications, in particular, peri-implantitis, thrombus formation, osteopenia, and osteoporosis.
The purpose of the work is to study the genetic determinants of osteogenesis disorders in order to develop effective methods of treatment and prevention of complications of dental diseases.
Research methods are molecular genetic, statistical.
Scientific novelty. Potential genetic risk markers for the development of osteopenia and periodontitis in conditions of dental diseases were identified. It was established that single-nucleotide polymorphisms rs2073617 950C>T in the TNFRSF11B gene and rs6757845 G>A in the ZNF385B gene can be risk markers for the development of osteopenia, and the A-allele of rs6757845 is also a risk factor for periodontitis. It is important that the colonization of the oral cavity by the periodontopathogen P. gingivalis is associated with both osteopenia and periodontitis on its background, which emphasizes the role of this microorganism in the development of accompanying pathologies. In addition, polymorphisms rs865429 of the SOST gene, rs2277438 of the TNFSF11 gene, and rs41494349 of the LRP5 gene did not show significant associations with the risk of developing osteopenia and periodontitis, which requires further studies to clarify their minor effects. This study is the first to examine these genetic determinants in the context of dental disease risks, making it particularly relevant for the development of effective prevention and treatment strategies.
3 articles were published in professional journals.
Product Description
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Adubetska Alina Yu.
Verbytskaia Tomara H.
Vyshnevska Hanna O.
Horokhivskyi Volodymyr N.
Hurtova Yana M.
Nepriakhina Oksana V.
Skyba Oleksandra V.
Khomiakov Mykhailo K.
Shumilina Kateryna S.
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2025-01-10
