Registration Number
0225U000712,
(0122U002235)
, R & D reports
Title
Synthesis and investigation of halogen-containing polymethine dyes and luminophors
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Синтез та дослідження галогеновмісних поліметинових барвників та люмінофорів
Head
Tatarets Anatolii L., к.х.н.
Registration Date
16-01-2025
Organization
State Scientific Institution Scientific and Technological Complex" Institute of Single Crystals "of the National Academy of Sciences of Ukraine
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Development of novel halogen-containing polymethine dyes and luminophors and their investigation as components of functional materials.
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The main goal of the work was to develop new halogen-containing polymethine dyes and luminophores and to study them as components of functional materials, in particular for theranostics, photodynamic therapy, and photoimmunotherapy.
In this work, for the first time: a systematic series of heptamethinecyanine dyes with different numbers (from 1 to 6) of iodine or bromine atoms in the terminal heterocyclic fragments was synthesized; the relationship between the structure and properties of halogenated heptamethinecyanine dyes depending on the number and position of halogen atoms was investigated; кegularities have been identified for controlling the key properties of heptamethinecyanine dyes (fluorescence quantum yield and singlet oxygen generation quantum yield) by adjusting the number and positions of halogen atoms; the influence of the number of iodine atoms in heptamethinecyanines on the photocytotoxic effect against bacteria was evaluated; it was shown that iodinated heptamethinecyanine dyes are suitable for the treatment and photoinactivation of Gram-positive and Gram-negative bacteria; a cyanine dye-monoclonal antibody conjugate was obtained, which was proposed for use in photoimmunotherapy and demonstrated its effectiveness in cancer theranostics.
This study contributes to the development of cyanine NIR dyes for fluorescence imaging, diagnostics, photodynamic therapy and theranostics. The practical value of the work lies in the ability to provide the dyes with the desired properties. Dyes have been developed that are effective for photoeradication of bacteria, avoiding the possibility of bacterial resistance to drugs. The presence of a carboxyl group allows further binding of these dyes to biological carriers. Heptamethinecyanine-based conjugates have been shown to be effective for in vivo diagnosis and treatment of cancer in photoimmunoassay protocols. Thus, this study expands the possibilities of near-infrared cyanine dyes for biomedical application.
Product Description
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Ananieva Valeriia V.
Biziaieva Yuliia V.
Burenkov Ivan O.
Vashсhenko Andrii P.
Vlasenko Hanna S.
Volokitin Yurii O.
Hovor Iryna V.
Kaidash Mariia B.
Kobzev Dmytro V.
Kolosova Olha S.
Kryvoshei Oleksandr I.
Kulyk Olesia H.
Obukhova Olena M.
Popova Kateryna V.
Svoiakov Rostyslav Р.
Semenova Olha M.
Starko Serhii M.
Stepanenko Olena Yu.
Tatarets Anatolii L.
Fediuniaieva Iryna A.
Chernyshova Oksana S.
Shсhyrova Nataliia V.
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2025-01-16
