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Information × Registration Number 0225U000823, (0123U102780) , R & D reports Title To develop a personalized prognosis of the course of СОВИД-19 in children based on markers of hereditary predisposition popup.stage_title Розробити персоніфікований прогноз перебігу СОVID-19 у дітей на підставі маркерів спадкової схильності Head Antypkin Yurii H., Доктор медичних наук Registration Date 20-01-2025 Organization State institution «Ukrainian center of maternity and childhood of the National academy of medical sciences of Ukraine» popup.description1 To determine the diagnostic and informative molecular genetic markers for the prognosis of the severity of the course of СОВИД-19 in children for the prevention and personalized therapy of the disease. popup.description2 As a result of the work, it was found that the mild course of COVID-19 in the examined children was characterized by fever, rhinopharyngitis, and among the clinical manifestations of the severe course of the disease, signs of bilateral pneumonia with respiratory failure, pleurisy and laboratory changes (erythropenia, increased CRP and AST). The presence of concomitant somatic pathology without JIA in children with COVID-19 did not affect the severity of the disease. However, among children who had concomitant pathology without JIA, bilateral pneumonia developed more often. In the majority of children with JIA, COVID-19 was mild to moderate course, without lung damage. The clinical symptoms of children with JIA who had COVID-19 were dominated by symptoms of intoxication, cardialgia, myalgia, and arthralgia. In 26.6% of children after COVID-19, joint syndrome with the development of JIA debuted. It has been proven that the GG rs1800795 genotype of the IL-6 gene is associated with a more severe course of COVID-19 among all groups. The TT genotype according to the polymorphism rs12979860 of the IFN-λ gene is associated with a predisposition to the development of COVID-19 among children, including JIA, and its CC genotype is a protective marker of severe COVID-19. The combination of the DD genotypes of the ACE 1 gene and the CG genotype of the TLR4 gene is associated with a severe course of COVID-19, while the combination of the GG genotype of the VDR gene and the G allele of the IL-6 gene, combination of the GC genotypes of the IFNL gene and the G allele of the TLR4 gene are protective against lung damage. Children with severe COVID-19 have a significantly shorter relative telomere length, with lung damage had a longer relative telomere length compared to children without lung damage. The identification of informative variants of the studied candidate gene polymorphisms allowed the development a prognostic panel of molecular genetic markers of the severity of COVID-19. Product Description popup.authors Antypkin Yurii H. Harashchenko Tetiana A. Horodna Oleksandra V. Kaminska Tetiana M. Krasnenkov Dmytro S Livshyts Liudmyla A. Marushko Rostyslav V. Mukvich Olena M. Pinchuk Liudmyla P. Umanets Tetiana R. popup.nrat_date 2025-01-20 Close