Registration Number
0225U000839,
(0124U003095)
, R & D reports
Title
Study of dispersed systems as bases-vehicles for development of medicinal products
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Дослідження дисперсних систем як основ-носіїв для подальшого створення лікарських засобів
Head
Bezuhla Olena P., к.фарм.н.
Registration Date
20-01-2025
Organization
State Scientific Institution Scientific and Technological Complex" Institute of Single Crystals "of the National Academy of Sciences of Ukraine
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Study of the influence of various factors on the physicochemical and biopharmaceutical properties of dispersed systems
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The research aimed to study the correlation between the physical and chemical characteristics of the dispersed systems, their structure, and the release of active pharmaceutical ingredients.
The ability of aqueous solutions of poloxamers to undergo of sol ↔ gel transitions is dependent on their type, content, and temperature. As temperature rises, the packing density and orderliness of polypropylene oxide (PPO) chains in the core of poloxamer micelles decrease. As a result, the volume fraction of micelles increases, which may be one of the contributing factors to the transition of the sol to gel. The capacity of 20 % P338 solution to undergo a thermally induced sol ↔ gel transition is maintained if an ethanol concentration is not more than 5-10 % but propylene glycol (PG) concentration is not more than 10-30 %. A correlation has been identified between alterations in the rheological characteristics of 20 % P338 solution and modifications in the EPR spectra of the 5-DSA NH4 salt. As the PG concentration increases, the solvation of micelle cores is no observed. The thermodynamic activation parameters and excess thermodynamic activation parameters of viscous flow were determined for the mixed solvents water – PG. Sol ↔ gel transitions occur as long as the water structure dominates in the system. The poloxamer solutions become Newtonian liquids when the transition to mixed structures of solvent occurs. The changes in the viscosity of systems water – PG correlate with the alterations in the viscosity of the microenvironment of spin probe molecules. The viscosity of the microenvironment is also influenced by the interaction of spin probes with solvent molecules. The release rate and cumulative amount of dexpanthenol in the case of gels with different bases are contingent on the nature of the lyotropic liquid crystals that cause the formation of gels. The data obtained suggest the potential for the development of P-338-based topical pharmaceuticals.
Product Description
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Bezuhla Olena P.
Zinchenko Ihor O.
Lysokobylka Oleksыi A.
Liapunov Mykola O.
Liapunov Oleksii M.
Liapunova Anna M.
Pukhova Tetiana M.
Stolper Yurii M.
Shliapkina Yuliia V.
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2025-01-20
