Registration Number
0225U001118,
(0121U111554)
, R & D reports
Title
The determination of sex differences in cardiometabolic risk and rationale of the effectiveness of new agents for its pharmacological correction in prediabetes
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Визначення статевих відмінностей кардіометаболічного ризику та обґрунтування ефективності нових засобів для його корекції за умов предіабету
Head
Horbenko Nataliia I., Доктор біологічних наук
Registration Date
25-01-2025
Organization
State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine"
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To determine the biochemical factors’ features of cardiometabolic risk depending on sex to justify the effectiveness of sex-specific pharmacotherapy in prediabetes
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The purpose of the work is to establish the features of the biochemical factors of cardiometabolic risk depending on gender in order to justify the effectiveness of sex-specific pharmacotherapy under conditions of prediabetes. It was found that the metabolic syndrome leads to a more pronounced deterioration of carbohydrate tolerance and an increase in the mass of total visceral fat in male rats, while body weight gain and lipid metabolism disorders are more pronounced in female rats compared to males. It was found that the metabolic syndrome is accompanied by changes in the androgen-estrogen balance in experimental animals of both sexes. It has been established that the use of hop extract at a dose of 200 μg/kg (based on 8-prenylnaringenin) in female rats with hypoestrogenia contributes to the weakening of such manifestations of the metabolic syndrome as insulin resistance, glucose intolerance, visceral obesity, hypertriglyceridemia, oxidative stress, and endothelial dysfunction. and also reduces the concentration of fibrinogen, reduces depressive symptoms, normalizing research activities, weakens the development of cardiovascular dysfunction according to electrocardiogram data. The field of application is health care, clinical and experimental diabetology.
Product Description
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Ivanova Olha V.
Bielkina Inna O.
Borikov Oleksii Yu.
Burma Tetiana Yu.
Varavin Vitalii P.
Havrysh Tetiana S.
Horbenko Nataliia I.
Zavadska Nataliia V.
Kiprych Tetiana V.
Lizohubova Maiia H.
Leshсhenko Zhanna A.
Luhova Iryna A.
Popov Serhii B.
Seliukova Nataliia Yu.
Sydorova Iryna V.
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2025-01-25
