Registration Number
0225U001142,
(0122U200336)
, R & D reports
Title
Determining the role of single nucleotide polymorphisms of candidate genes on the effectiveness of different treatment options for type 2 diabetes mellitus and endocrine infertility
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Визначення ролі однонуклеотидних поліморфізмів генів-кандидатів щодо ефективності різних варіантів терапії цукрового діабету 2 типу та ендокриннообумовленого безпліддя
Head
Misiura Kateryna V., Доктор медичних наук
Registration Date
26-01-2025
Organization
State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine"
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Creating a new system to increase the effectiveness of prevention and treatment (while reducing financial costs) of hormonal and metabolic disorders - the basis of type 2 diabetes, endocrine infertility in the population of Ukraine under martial law and in the postwar period by creating pathogenetically determined approaches to demographic genetics in the population
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The objects of research are polymorphisms of candidate genes from the adipocytokine and transport link. The goal of the work is to create a new system for improving the effectiveness of the prevention and treatment of hormonal and metabolic disorders, of endocrine-related infertility in the population of Ukraine in the conditions of martial law and in the post-war period by creating pathogenetically determined approaches to taking into account genetic and demographic processes in the population. Against the background of the use of Omakor in the group of patients who took Metformin as the main hypoglycemic drug, an improvement in glycemic control indicators was found, decrease in the manifestations of insulin resistance, decrease in the level of free fatty acids, positive changes in the level of adipokine in the examined patients, which indicates the improvement of metabolic parameters in the body, decrease in local inflammation in adipose tissue. A comparative analysis of a number of biochemical indicators was carried out in groups that did or did not take Metformin as the main hypoglycemic drug. The study found that carriers of the AG genotype based on the Met408Val polymorphism of the SLC22A1 gene, who took metformin, had significantly lower levels of low-density lipoprotein cholesterol, total cholesterol, omentin, osteoprotegerin, ALT and AST. The field of application is health care, endocrinology
Product Description
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Arkhypkina Tetiana L.
Bielkina Inna O.
Bondarenko Volodymyr O.
Voropai Tetiana I.
Hievorkian Aida R.
Zemlianitsyna Olha V.
Kolesnikova Alla O.
Koshel Svitlana P.
Kravchun Nonna O.
Leshсhenko Zhanna A.
Lyubimova Lydia P.
Misiura Kateryna V.
Mykytiuk Myroslava R.
Ovcharenko Liliia B.
Perets Olena V.
Romanova Iryna P.
Sakhniuk Tetiana V.
Seliukova Nataliia Yu.
Sydorova Iryna V.
Tyzhnenko Tetiana V.
Tykha Inna A.
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2025-01-26
