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Information × Registration Number 0225U001385, (0122U001599) , R & D reports Title New metal-clinoptilolite compositions for analytical chemistry, biology and healthcare popup.stage_title Нові композиції метал-клиноптилоліт для потреб аналітичної хімії, біології та охорони здоров’я Head Kalychak Yaroslav М., Доктор хімічних наук Registration Date 30-01-2025 Organization Ivan Franko National University of Lviv popup.description1 Development of methods for concentration, separation and determination of Bi, Li, Er and Ho in waters and technological solutions based on methods of solid phase extraction, luminescence (LM), spectrophotometry (SPh), voltammetry (VA), flame photometry, X-ray analysis using Transcarpathian clinoptilolite (Clin) and its modified forms. Elaboration of the sorption-LM method for Er determination. The investigation of the possibility of LM compositions Clin – Er, Yb, Nd using for biovisualization in vivo in the visible and IR spectrum ranges. Investigation of Clin-REE, Clin-Ag-metronidazole and Clin-Bi (Zn) compositions for the cytotoxic and antimicrobial activity. Development of VA methods for determination of the alkaloids (quinine, galantamine) and their metabolites (N-oxides, cotinine) in biological fluids. Development of SPh method for Ceftriaxone determination in finished dosage forms. popup.description2 The sorption of trace amounts of Er on clinoptilolite (CL) occurs mainly by adsorption of neutral hydrolyzed forms. Ho is most efficiently sorbed from at pH 9.2. Methods for the concentration of Er and Ho using solid-phase extraction have been proposed. The differences in the sorption conditions of Er, Ho, Lu, and Gd make it possible to separate and selectively concentrate these lanthanides. Optimal conditions for the preparation of the luminescent (LM) composition “CL-Er-dibenzoylmethane-o-phenanthroline-ethonium” were found and a highly sensitive selective method for the sorption-LM determination of Er was developed. The range of concentrations of Er that are detectable is 15-150 ng/ml. The optimal conditions for obtaining upconversion LM compositions “Cl-Bi-Er-Yb” were found. The highest sorption capacity of Cl in relation to Bi(III) is shown at pH 2.5, it is possible to quantitatively concentrate and remove trace amounts of Bi(III) from solutions containing ions of various heavy metals, at such low pH values. It was found that Li+ is most efficiently sorbed from weakly acidic and neutral solutions on H-form of CL. New methods of spectrophotometric and kinetic determination of the ceftriaxone were developed. The biocompatibility of CL and compositions based on “CL-Er” was evaluated in tests with cultured normal and tumor cells. Selective methods for the determination of bioactive substances such as cotinine, quinine, and galantamine have been developed. The antimicrobial properties of the compositions “CL-Ag(Zn)”, “CL-Ag-metronidazole” and “CL-Ag(Bi)” were explored. The compositions with Bi(III) ions in different concentrations also show an antimicrobial effect. The toxicity and nature of the cytopathic effect of the compositions “CL-Ho” and “CL-Ag-metronidazole” were determined. A methodology for determining extracellular neutrophil traps has been established to estimate in the future the effect of the created zeolite compositions on phagocytosis. Product Description popup.authors Bahdai Svitlana R. Blazheievskyi Mykola Ye. Vistovskyi Vitalii V. Vasylechko Volodymyr O. Hamernyk Roman V. Hryshchuk Halyna V. Hromyko Oleksandr M. Dmukhailo Andrii V. Doletska Anastasiia S. Dubenska Liliia O. Dushna Olha M. Zhukrovska Kseniia-Oksana A. Kliuchivska Olha Yu. Korkuna Olha Y. Kostiv Oksana I. Ostap'iuk Larysa M. Panas Khrystyna V. Patsai Ihor O. Rybak Viktoriia I. Rydchuk Petro V. Slobodeniuk Kateryna S. Stoika Rostyslav S. Tymoshuk Oleksandr S. Fedyshyn Orest S Fedorenko Victor О. Shevchuk Liubomyr M. popup.nrat_date 2025-01-30 Close