Registration Number
0225U001604,
(0124U001414)
, R & D reports
Title
Development of hemostatic hydrogel and microneedle transdermal patches for immediate stabilization of the wounded in combat conditions
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Вибір компонентного складу, дослідження та визначення оптимальних режимів одержання новітніх кровоспинних трансдермальних гідрогелів на основі біоматеріалів
Head
Olkhovska Anzhela B., Доктор фармацевтичних наук
Registration Date
03-02-2025
Organization
National Technical University "Kharkiv Polytechnic Institute"
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The goal is to develop and create, on the basis of biocompatible biodegradable antiseptic biomaterials and their composites with humic acids, effective hemostatic hydrogels and hemostatic plasters with high adhesion to mobile and moist damaged surfaces of the body for the immediate stabilization of the wounded in combat conditions and for the purpose of providing timely and effective first aid on the battlefield.
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The aim of the work is to create effective hemostatic biopolymer biologically active hydrogels that are able to turn into sol and become liquid on the wound surface, penetrate to the source of bleeding, quickly swell and secrete a hemostatic agent, initiating the blood coagulation cascade and ensuring rapid hemostasis. Effective biocompatible and biodegradable hemostatic gelatin-alginate hydrogels with antibacterial properties due to modification with humic acids and with hemostatic action due to impregnation with aminocaproic acid have been developed, which, due to the gel-sol transition at physiological temperature, are able to become liquid on the wound surface, penetrate to the source of bleeding, thicken the blood due to swelling and secrete a hemostatic component into the wound, ensuring rapid hemostasis. In vitro experiments have proven that the thermosensitive bioactive biopolymer hydrogels we have developed are promising for use in hemostatic dressing materials.
Product Description
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Voronkin Andrii A.
Hrubnyk Ihor M.
Kariev Artem I.
Klochko Natalia P.
Lebediev Volodymyr V.
Lebedieva Kateryna O.
Cherkashyna Hanna M.
Yudina Yuliia V.
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2025-02-03
