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Information × Registration Number 0225U001656, (0122U001319) , R & D reports Title Study of the role of coagulation disorders, clinical-morphological and molecular-genetic disorders in the development of therapeutic response in patients with myeloproliferative diseases affected by the Chornobyl accident popup.stage_title Аналіз асоціативних зв’язків між наявністю коагулогічних розладів, клініко-морфологічними, молекулярно-генетичними порушеннями у формуванні відповіді на терапію для створення комплексу прогностичних критеріїв оцінки перебігу захворювання у пацієнтів з гострими та хронічними мієлопроліферативними захворюваннями, постраждалих внаслідок аварії на Чорнобильській АЕС та контрольної групи. Head Diahil Iryna S., Доктор медичних наукMinchenko Zhanna M., д.б.н. Registration Date 04-02-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 Тo evaluate the contribution of coagulation disorders, clinical, morphological and molecular genetic deviations in the pattern of response to therapy in patients with myeloproliferative diseases affected by the Chornobyl accident and the control group in the development of prognostic criteria set for the course of the disease popup.description2  128 patients were examined (AML – 80, CMPD– 48), among them 17 victims of the Chornobyl accident. On the background of specific clinical and laboratory changes for acute myeloid leukemia and chronic myeloproliferative diseases, fluctuations in coagulogram parameters were established, regardless of the radiation factor, indicating the development of hypocoagulation and impaired protein-synthesizing liver function. The overall survival rate of patients with AML is 60.8%, which corresponds to world statistics. Cytogenetic study confirmed specific mutations for patients with AML and CMPD. For patients with PMF with a radiation history, the development of pronounced bone marrow fibrosis is characteristic. The frequency of a decrease in ristocetin cofactor activity (vWF:RCo) < 50% is associated with the appearance of spontaneous bleeding in groups G2–G4 in patients with AML. The highest frequency of hemorrhagic syndrome of G2–G4 degree is recorded at a median platelet count of 34.5 G/l. Studies of vWF:RСo, vWF:Ag, vWF:FVIII in patients with AML classified as groups G2–G4 are extremely necessary for correcting treatment tactics, reducing the severity of bleeding manifestations and increasing the chances of avoiding severe complications in the induction period of therapy, regardless of radiation history. To reduce the risk of developing hemorrhagic complications, stratification is performed with the definition of group G2–G4. If factor VIII deficiency is detected, factor VIII drugs, desmopressin, etc. should be included in the treatment regimen and these violations should be taken into account at the next stages of treatment. Product Description popup.authors Martina Zoia V. Selina Iryna O Stupakova Zinaida V. Fedorenko Vira H. Sholoiko Valentyna V. popup.nrat_date 2025-02-04 Close