Registration Number
0225U002165,
(0122U000327)
, R & D reports
Title
To study the structural-molecular characteristics and parenchymal-stromal interactions of brain tumor cells to determine prognostic markers and potential targets to justify targeted therapy
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Вивчити структурно-молекулярні характеристики і паренхіматозно-стромальні взаємодії клітин пухлин головного мозку з метою визначення прогностичних маркерів і потенційних мішеней для обґгрунтування спрямованої терапії
Head
Malysheva Tatiana А., Доктор медичних наук
Registration Date
21-02-2025
Organization
The State Institution "Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine"
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Improving the quality of care (morphological diagnosis, theoretical justification of differentiated treatment tactics) for brain tumors
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Report on the GDR: 166 pp., 65 figures, 18 tables, 95 sources.
BRAIN, TUMORS, GLIOMAS, MORPHOLOGY, STROMA, PARENCHYMA, CELLULAR INTERACTIONS, BIOMARKERS, PLATES, RB1 GENE FAMILY, SPECTRAL ANALYSIS.
Violation of intercellular synaptic contacts and violation of the structure of the BBB was revealed, the characteristics of the HG have a high statistically significant effect on the probability of the risk of continued tumor growth according to the histological criteria of calcification (OR = 45.21) and hemorrhage (OR = 23), which are individual metabolic characteristics. With hemorrhages, the probability of the risk of recurrence is 23 times higher than in its absence, the sensitivity of the model is 88%, the specificity is 75%. If there are lymphocytes above 35 in the field of vision, the probability of recurrence is 1.08 times higher (sensitivity of the model – 73%, specificity – 79%). The odds of relapse are 1.54 higher with CD68+ cells in the HG. The ratio of neutrophils to lymphocytes, the index of systemic inflammation increases 2-3 times with the increase in the degree of malignancy of the tumor. Glioblastomas are characterized by a lack of expression of both the RB1 gene at the mRNA and protein levels, compared to embryonic brain tumors in children. Individual links of morphogenesis of intracerebral tumors were studied, structural and ultrastructural characteristics of intracerebral tumors were established, individual characteristics of the stromal component were objectified
Product Description
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Yehorova Diana Mykhailivna
Vaslovych Viktoriia V.
Hnatiuk Olena M.
Dashchakovskyi Andrii V.
Dovbeshko Halyna I.
Kashuba Olena V.
Kovalevska Larysa M.
Liubych Larysa D.
Morozov Tenhiz A.
Rozumenko Artem V.
Staino Larysa P.
Chernenko Oksana H.
Chuvashova Olha Yu
Shmelova Hanna A.
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2025-02-21
