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Information × Registration Number 0225U002367, (0123U100100) , R & D reports Title Hormonal-receptor status of tumor microenvironment cells as a factor in the modulation of oncogenesis in the endometrium and breast cancer popup.stage_title Визначення вмісту FOXP3-позитивних лімфоцитів у стромальному компонеті та аналіз експресії CXCL12, CXCR4, HGF, c-Met, TGFβ і рецепторів естрогенів і прогестерону у пухлин-асоційованих фібробластах та пухлинних клітинах карцином ендометрію та молочної залози. Head Buchynska Liubov H., Доктор біологічних наук Registration Date 05-03-2025 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description1 To establish the role of steroid hormone receptors (estrogens and progesterone) in determining the phenotypic features of the microenvironment of endometrial and breast carcinomas associated with the aggressiveness of the tumor process. popup.description2  Based on the analysis of the results of a comprehensive clinical, morphological and immunohistochemical study, it was found that a slight lymphocytic infiltration is associated with a high content of FOXP3+-lymphocytes in the tumor microenvironment and the presence of tumor emboli in the vessels. The significance of CXCR4 and CXCL12 expression in tumor cells and the content of CXCL12+-fibroblasts in the stromal microenvironment as key factors involved in the formation of the invasive-metastatic phenotype of endometrial and breast cancer of the luminal A subtype is shown. It has been established that high expression of the chemokine receptor CXCR4, low expression of its ligand CXCL12 in tumor cells, and increased content of CXCL12+-fibroblasts in the stromal component of tumors correlate with vascular invasion of endometrial carcinomas and the presence of metastases in regional lymph nodes in patients with the Luminal A subtype of breast cancer. Cell lines of different degrees of malignancy were characterized: basal (MDA-MB-231) and luminal (MCF-7) subtypes of breast cancer by CXCR4 expression. It was established that CXCR4 expression is reduced in MDA-MB-231 cells compared to MCF-7. The obtained data reflect the aggressiveness of the tumor process, which necessitates the search for individualized approaches to the treatment of such patients. Product Description popup.authors popup.nrat_date 2025-03-05 Close