Registration Number
0225U002683,
(0124U000752)
, R & D reports
Title
Development of bioactive implants for restoration of lost large bone fragments after gunshot wounds based on the principle of induced membrane
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Розробка біоактивних імплантатів для відновлення втрачених великих фрагментів кісток після вогнепальних поранень за принципом індукованої мембрани
Head
Firstov Serhii O., д.ф.-м.н.
Registration Date
28-03-2025
Organization
Frantsevich Institute for Problems of Materials Science National Academy of Science of Ukraine
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Creation of porous, biosoluble implants from modified bioactive ceramics with various functional properties (osteoinductive, antiviral, antibacterial) in combination with the autocells or osteoinducers for restoration of lost bone tissue large fragments after gunshot wounds (more than 6 cm) using the induced membrane technique
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The objects of development are modified bioactive ceramics with various functional properties, products made of bioactive ceramics (BC) manufactured using 3D printing.
The purpose of the work is to develop bioactive implants from modified calcium phosphate ceramics (MCPC) for the restoration of lost bone fragments of critical size using the induced membrane technique (IMT). To develop IMT in in vivo experiments on rabbit limbs.
Implants from modified bioactive ceramics have been created for use in IMT operations. IMT has been developed for the restoration of bone tissue using different types of bioactive ceramics in different membranes after the removal of critical size limb fragments in rabbits. The optimal combination of the membrane and BC has been determined. The shortcomings of IMT have been identified and ways to eliminate them have been proposed. Criteria for assessing the readiness of the induced membrane for the second stage of the operation to replace the MCPC spacer have been determined. The adhesion, survival and differentiation of autologous stem cells into bone cells on different types of MCPCs were studied, which confirmed their behavior in bone tissue. Histological studies of the restored bone tissue in the membrane were conducted after implantation of different ceramic samples for different periods. with and without autologous cells, the requirements for MCPCs for its use in the restoration of lost critical fragments of limbs using the induced membrane technique were determined.
The results of the work will be used in the treatment of wounded people with losses of bone fragments of critical size.
Product Description
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Mykhailo V. Rublenko
Firstov Serhii O.
Tetiana P. Vladimirova
Ulianchych Nataliia V.
Kolomiiets Volodymyr V.
Strilets Larysa P.
Horna Iryna D.
Bublei Oleksandr Yu.
Oksana S. Koryak
Alona V. Zlatska
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2025-03-28
