Registration Number
0225U002721,
(0123U101953)
, R & D reports
Title
Chemical burns of various genesis: mechanisms of local and systemic implementation, therapeutic correction using carbon nanocomposites.
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Створення вуглецевих нанокомпозитів із різними біологічними властивостями.
Head
Dziubenko Nataliia V., Кандидат біологічних наук
Registration Date
01-04-2025
Organization
Taras Shevchenko National University of Kyiv
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The aim of the project is to study the patterns of development and regeneration of a burn injury of a chemical nature and the possibilities of its specific correction using carbon nanocomposites with different surface chemistry.
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It was shown that the studied carbon nanocomposites synthesized from urea by the solvothermal method (CD) and from coffee beans by the “green synthesis” method (CCAM) are relatively non-toxic when applied systemically. These composites exert a significant healing effect in the case of alkali-induced burns, which, however, are much less effective in the case of acid burns, which is not obvious given the mechanisms of development of burn chemically-induced lesions and the properties of the studied nanocomposites. It was also shown that the healing effect of nanocomposites also causes the normalization of immune imbalance, i.e. there is a systemic effect (which is expected). However, the effect of the studied nanocomposites on hematological parameters in acid and alkaline burns was somewhat different, although in general, changes in hematological parameters correlated with the severity of the burn lesion. The latter may be the basis for predicting the effectiveness of treating burn lesions with one or another agent.
Product Description
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Ishchuk Arsen М.
Bielinska Iryna V.
Kuznietsova Halyna M.
Lysenko Artemii V.
Lysenko Tetiana L.
Milokhov Demyd S.
Rybalchenko Таras V.
Stupak Yuliia A.
Khylia Olha V.
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2025-04-01
