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Information × Registration Number 0225U003080, (0123U100179) , R & D reports Title To investigate the toxicity and therapeutic activity of food additives carrageenans (E407/E407a) and their oligosaccharide fragments as modulators of programmed cell death popup.stage_title Дослідити токсичність й терапевтичну активність харчових добавок карагенанів (Е407/Е407а) та їх олігосахаридних фрагментів в якості модуляторів програмованої клітинної загибел Head Nakonechna Oksana A., д.мед.н. Registration Date 15-05-2025 Organization Kharkiv National Medical University popup.description1 Research on the safety and effectiveness of the use of food additives carrageenans (E407/E407a) and their oligosaccharide fragments as therapeutic agents capable of modulating programmed cell death (PCD), namely eryptosis, necroptosis, ferroptosis and autophagic type of PCD popup.description2  The ability of different forms of carrageenans and their oligosaccharide fragments to induce programmed cell death, namely apoptosis, eryptosis, has been established. A literature review has been conducted, research has been carried out into the influence of different industrial forms of carrageenan on the physicochemical properties of erythrocyte and leukocyte membranes, and it has been established that carrageenans of different structures have opposite effects, causing different changes in the phospholipid composition of erythrocyte membranes. It has been established that t-, k-, λ- carrageenans cause apoptosis, eryptosis, which depends on the development of oxidative stress and is Ca2+ dependent. It has been established that λ-carrageenan is the most powerful inducer of leukocyte apoptosis and eryptosis, which changes the cell volume, promotes the translocation of phosphatidylserine in the membrane and causes the accumulation of Ca2+ inside the cell. Product Description popup.authors Bachynskyi Ruslan O. Vasyleva Iryna M. Horbach Tetiana V. Miasoiedov Valerii V. Nakonechna Oksana A. Posokhov Yevhen O. Prokopiuk Volodymyr Yu. Yankovska Dariia O. popup.nrat_date 2025-05-15 Close