Registration Number
0225U003210,
(0122U000352)
, R & D reports
Title
Pathogenetic substantiation of diagnosis and prognosis of fibrotic and metabolic disorders in patients with non-alcoholic fatty liver disease on the background of hypertension
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Патогенетичні обґрунтування діагностики та прогнозування фібротичних та метаболічних порушень у пацієнтів з неалкогольною жировою хворобою печінки на тлі гіпертонічної хвороби
Head
Zhelezniakova Nataliia M., д.мед.н.
Registration Date
02-06-2025
Organization
Kharkiv National Medical University
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Optimization of diagnosis of non-alcoholic fatty liver disease and hypertension, insulin resistance and overweight patients based on the study of their metabolic and vascular parameters
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In patients with comorbid nonalcoholic fatty liver disease and hypertension, changes in liver enzymatic status (increased levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase), lipid metabolism (increased levels of total cholesterol, triglyceride, and decreased levels of high-density lipoprotein) and increased insulin resistance (insulin and HOMA-IR index) were observed. In addition, changes in the functional state of the endothelium (decreased levels of eNOS, endothelium-dependent vasodilation of the brachial artery, increased levels of fibrinogen) and indicators of the systemic inflammatory response (increased levels of CRP, hsCRP, IL-6, IL-1β, pentraxin-3, decreased levels of IL-4, IL-10, and kallistatin) were determined. A comprehensive assessment of these indicators is one of the criteria for non-invasive diagnosis of metabolic disorders and prediction of fibrotic changes in the liver in patients with non-alcoholic fatty liver disease on the background of hypertension.
Product Description
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Aleksandrova Tetiana M.
Vizir Maryna O.
Hoptsii Olena V.
Zhelezniakova Nataliia M.
Zaichenko Olha Ye.
Karpenko Iryna I.
Klimenko Mykola I.
Laphyna Kateryna A.
Molodan Volodymyr I.
Ovcharenko Liudmyla I.
Panchenko Halyna Yu.
Prosolenko Kostiantyn O.
Rozhdestvenska Alesia O.
Tverezovska Iryna I.
Frolovа-Romaniuk Elina Yu.
Shalimova Anna S.
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2025-06-02
