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Information × Registration Number 0225U003233, (0123U101083) , R & D reports Title Cellular and humoral mechanisms of neuroprotection in in vivo and in vitro models of brain damages popup.stage_title Дослідження дії пошкоджуючих чинників різного ґенезу на стан нервової тканини Head Skybo Halyna H., Доктор медичних наук Registration Date 04-06-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 Investigation of factors that have the neuroprotective potential in conditions of experimental brain damage simulation, and analysis of cellular and humoral mechanisms of neuroprotection popup.description2  The effective concentration of metabolic products from the experimental strain Lacticaseibacillus rhamnosus was determined, demonstrating its neuroprotective effect on hippocampal cells and enteric nervous system cells of the intestine under in vitro conditions simulating damage through oxygen-glucose deprivation and bacterial lipopolysaccharide exposure. Behavioral tests conducted at different stages of postnatal development (3, 5 days and 1 month) assessed neurological disorders in offspring of mice with LPS-induced inflammation. The corrective effects of probiotics (Lactococcus lactis and Lactobacillus rhamnosus) were also evaluated. In an in vivo model of ischemic brain injury, immunoelectron microscopy with colloidal gold-labeled antibodies revealed myelination of axons in cortical neurons of recipient rats by oligodendrocytes derived from human neuroepithelial stem cells and transplanted into the rat cerebral cortex. The effect of proliferative activity of resident immune cells (astrocytes and microglia) in substantia nigra tissue on the intensity of the local inflammatory response was investigated in the rotenone-induced hemiparkinsonism model. Product Description popup.authors Zhovannyk Valeriia O. Kovalenko Tetiana M. Lushnikova Iryna V. Nikonenko Oleksandr H. Osadchenko Iryna O. Patseva Maryna A. Skibo Halyna H. Smozhanyk Kateryna H. Tsupykov Oleh M. Shchepanskyi Serhii O. popup.nrat_date 2025-06-04 Close