Registration Number
0225U003233,
(0123U101083)
, R & D reports
Title
Cellular and humoral mechanisms of neuroprotection in in vivo and in vitro models of brain damages
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Дослідження дії пошкоджуючих чинників різного ґенезу на стан нервової тканини
Head
Skybo Halyna H., Доктор медичних наук
Registration Date
04-06-2025
Organization
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
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Investigation of factors that have the neuroprotective potential in conditions of experimental brain damage simulation, and analysis of cellular and humoral mechanisms of neuroprotection
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The effective concentration of metabolic products from the experimental strain Lacticaseibacillus rhamnosus was determined, demonstrating its neuroprotective effect on hippocampal cells and enteric nervous system cells of the intestine under in vitro conditions simulating damage through oxygen-glucose deprivation and bacterial lipopolysaccharide exposure.
Behavioral tests conducted at different stages of postnatal development (3, 5 days and 1 month) assessed neurological disorders in offspring of mice with LPS-induced inflammation. The corrective effects of probiotics (Lactococcus lactis and Lactobacillus rhamnosus) were also evaluated.
In an in vivo model of ischemic brain injury, immunoelectron microscopy with colloidal gold-labeled antibodies revealed myelination of axons in cortical neurons of recipient rats by oligodendrocytes derived from human neuroepithelial stem cells and transplanted into the rat cerebral cortex.
The effect of proliferative activity of resident immune cells (astrocytes and microglia) in substantia nigra tissue on the intensity of the local inflammatory response was investigated in the rotenone-induced hemiparkinsonism model.
Product Description
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Zhovannyk Valeriia O.
Kovalenko Tetiana M.
Lushnikova Iryna V.
Nikonenko Oleksandr H.
Osadchenko Iryna O.
Patseva Maryna A.
Skibo Halyna H.
Smozhanyk Kateryna H.
Tsupykov Oleh M.
Shchepanskyi Serhii O.
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2025-06-04
