Registration Number
0225U003391,
(0122U001592)
, R & D reports
Title
A study of the theology of neuropathic pain in patients after spinal nerve injury
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Проведення дослідження профілю цитокінів у пацієнтів хвороби яких викликані детектованими токсинами у великих концентраціях.
Head
Shulga Serhii M., Доктор фізико-математичних наук
Registration Date
24-06-2025
Organization
V.N. Karazin Kharkiv National University
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The aim of the project is to establish a correlation between the concentration of toxic substances and changes in the profile of cytokines in patients with neuropathic pain after spinal cord injury. This requires a number of intermediate objectives:
- to study the profile of cytokines in patients with botulism and other bacterial infections associated with neuroparalytic syndrome
- to study Raman spectra of blood serum of patients with botulism and other bacterial infections and to establish the dependence of the cytokine profile on the concentration of toxic substances
- to create metal surfaces that enhance the cross-sectional scattering cross section 108 times and have resonance at the wavelength of the excitation laser
- to create a technique based on the Gorsky effect, the deposition of serum drops of patients on the metasurface, which provides an opportunity for the deposition to create conditions for denaturation of the tail of the toxic substance. Which is an important condition for increasing the cross-sectional scattering of the biolayer
- Creating an effective step-by-step instruction of changes to the actions of clinicians when diagnosing patients with unspecified pathology.
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The object of the study is a history of neuropathic pain in patients with spinal nerve damage and a study of the immune response in patients with various neuroparalytic pathologies to establish a connection between the pathogen and the cytokine profile.
The subject of the study is resonance effects that make it possible to detect toxic substances in extremely low concentrations that lead to the occurrence of neuropathic pain.
The purpose of the work is to establish a correlation between the concentration of toxic substances and changes in the cytokine profile in patients with neuropathic pain after spinal nerve injury and to develop metasurfaces that are capable of enhancing the Raman spectra of the corresponding toxins in the blood serum of patients.
Research methods – finite difference method in time domain, quantum mechanical modeling of complex biological molecules based on Gaussian 9.0, SERS.
Results of the work: a marker of oxidative stress, represented by the trinitrotyrosine molecule, was discovered; a quantum-mechanical model was constructed for this model, which allowed determining the structure of electron-vibrational interactions in it and constructing the structure of the molecule's spectrum using Raman spectroscopy; a mathematical model of a metastructure based on AgCl-Ag was developed, which is capable of enhancing the Raman spectrum of toxic molecules and detecting them in complex solutions such as, for example, blood serum.
Product Description
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Biloshenko Kostiantyn S.
Lavrentieva Olha Yu.
Mits Mykola H.
Rybin Oleh M.
Riabenko Hanna I.
Riabenko Yuliia A.
Sichevska Larysa V.
Stryzhko Serhii M.
Tashchenko Hanna V.
Tuz Volodymyr R.
Shulha Olena M.
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2025-06-24
