Registration Number
0225U003984,
(0125U003284)
, R & D reports
Title
Fine structural alterations of the neurogenic niche in Alzheimer’s disease
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Ультраструктурний аналіз 3D-реконструйованих периваскулярних відростків стовбурових клітин у здорових контрольних мишей Nestin-GFP.
Head
Tsupykov Oleh M., Доктор медичних наук
Registration Date
08-10-2025
Organization
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
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This project aims to explore the intricate morphological interactions between adult neural stem cells (aNSC) and their neurogenic niche, specifically investigating the alterations in Alzheimer's disease (AD). Focusing on two key questions, the study seeks to understand changes in structural interactions between aNSC, astrocytes, and microglia in AD using a common mouse model. Additionally, the project examines the impact of vascular amyloidosis on aNSC perivascular processes, exploring potential dysregulation of proliferation in the context of AD. By employing advanced microscopy techniques, this research aims to uncover crucial insights into the pathogenesis of AD, offering a foundation for understanding aNSC regulation within the neurogenic niche.
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This project aims to explore the intricate morphological interactions between
adult neural stem cells (aNSC) and their neurogenic niche, specifically
investigating the alterations in Alzheimer's disease. During the first stage of
the project, the ultrastructural features of Nestin-GFP-positive perivascular
processes of stem cells and their contact with capillaries and the basal lamina
were investigated using a JEM-100CX transmission electron microscope
(JEOL, Japan). The obtained data will serve as a basis for a comparative
analysis of the perivascular processes of stem cells in healthy control animals
with those in transgenic Nestin-GFPxAPP PS1 mice with an Alzheimer’s
disease model during the second stage of the project.
Product Description
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Halyna H. Skybo
Iryna V. Lushnikova
Serhii O. Shchepanskyi
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2025-11-03
