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Registration Number

0225U004389, (0124U004031) , R & D reports

Title

Development of biopolymer nanocomposite materials to stimulate the regeneration of living tissues and wound healing

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Біополімерні гелеві матеріали на основі альгінової кислоти, полівінілового спирту та наночастинок Ag чи ZnO

Head

Demchenko Valerii L., Доктор хімічних наук

Registration Date

03-12-2025

Organization

E. O. Paton Elektric Welding Institute National Academy of scinces of Ukraine

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The goal of the project is to develop crosslinked biopolymer nanocomposite gel materials based on polyvinyl alcohol, polysaccharides of various origins, hyaluronic, alginic, and γ-polyglutamic acid, and Ag or ZnO nanoparticles to stimulate the regeneration of living tissues and wound healing.

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Polymeric cryogel materials were developed based on polyvinyl alcohol polymer (which performed the function of crosslinking the polymer matrix), alginic acid (which performed the function of regenerating living tissues), and Ag2O and ZnO nanoparticles, which have a bactericidal effect. Crosslinking of samples with subsequent formation of hydrogels was performed by freezing-thawing. Ag2O and ZnO nanoparticles in the polymer matrix were formed in the process of forming hydrogels during the reduction of silver and zinc salts with alginic acid. The formation of Ag2O and ZnO nanoparticles in the polymer matrix was confirmed by X-ray structural analysis and Raman spectroscopy. It was found that samples with a shorter freezing time have a higher water absorption capacity. This effect is important in the sorption of wound exudate from the wound surface. It was found that the tensile strength and relative deformation of hydrogel materials decrease with increasing freezing time of samples. Cryogel materials based on polyvinyl alcohol, alginic acid and Ag2O or ZnO nanoparticles showed a bactericidal effect against a wide range of microorganisms, including activity against both gram-positive (S. aureus, S. epidermidis) and gram-negative bacteria (E. coli, P. aeruginosa). The effectiveness of the antimicrobial effect of cryogel materials proportionally depends on the concentration of Ag2O and ZnO nanoparticles in the PVA-AA polymer matrix from 0.01 to 1.0 wt %. Studies of the cytotoxicity of cryogel materials were conducted on cultures of epithelial cells MDBK (bovine kidney cells) and L-929 (mouse fibroblasts). It was found that at low concentrations of Ag2O and ZnO nanoparticles (0.01 and 0.05 wt %) in the polymer matrix, the samples do not exhibit a cytotoxic effect.

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Zahorodnia Svitlana
Maksim V. Yurzhenko
Podpriatov Serhii S.
Rybalchenko Nataliia P.
Demchenko Olena M.
Sytnyk Illia O.
Oleksandr A. Burianov

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2025-12-03