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Information × Registration Number 0225U005004, (0122U002240) , R & D reports Title The role of immunomodulatory in the antitumor action of traditional and experimental medicines at their delivery by polymeric nanocarriers to various target cells in vitro and in vivo popup.stage_title Вивчення впливу створених комплексів ландоміцинів А і Е із полі-2-оксазоліновим наноносієм на розподіл імунокомпетентних клітин в крові лабораторних мишей з меланомою В16, резистентною до хіміотерапевтичних чинників, та з лімфомою NK/Ly Head Stoika Rostyslav S., д.б.н. Registration Date 23-12-2025 Organization Institute of Cell Biology of the National Academy of Sciences of Ukraine popup.description1 The aim of the project is to investigate the role of immunomodulatory in the antitumor action of traditional and experimental medicines in free form and in complexes with synthetic and polymeric nanovectors. popup.description2 The general toxicity of 4-thiazolidinone derivatives (Les-6287 and Les-6294) was investigated in healthy mice. It was demonstrated that these compounds at 500 mg/kg did not induce significant changes in key hematological parameters or organ weight indices compared to control groups, indicating their biocompatibility and low toxicity, even after prolonged administration (22 days). In contrast, doxorubicin (20 mg/kg) caused pronounced hematological disturbances and a decrease in liver and kidney weights, confirming its systemic toxicity.Les-6287 and Les-6294 inhibit tumor growth of NK/Ly lymphoma in mice and improve animal survival to an extent comparable to doxorubicin, but without associated hematological abnormalities or changes in organ weights. To enhance the bioavailability of 4-thiazolidinone derivatives, α- and β-cyclodextrins were used, which significantly increased their aqueous solubility. The effects of immobilization of landomycin A and 9-O-octylberberine on poly(2-oxazoline)-based carriers on cellular uptake and apoptosis induction in malignant cells were studied in vitro. The most stable and biocompatible complexes with high antitumor activity were investigated in vivo using B16F10 melanoma and chemotherapy-resistant B16F10/adr models. Chitosan–antibiotic complexes were developed, and variants with high antimicrobial activity and minimal toxicity were selected. It was shown to exert no toxic effects on NIH 3T3 fibroblasts or HaCaT keratinocytes, whereas chloramphenicol at high concentrations caused cellular damage. An effective chitosan-based hydrogel for the treatment of infected wounds in mice was developed. The use of a hyaluronate-coated hydrogel accelerated the healing of wounds infected with Pseudomonas aeruginosa and Staphylococcus aureus. Functionalization of the hydrogels with ampicillin significantly enhanced their antibacterial activity. The MTT assay confirmed the absence of toxic effects of chitosan hydrogels on fibroblast viability. Product Description popup.authors Rostyslav R. Panchuk Maxim D. Lootsik Yuliia V. Senkiv Nataliya I. Kashchak Volodymyr O. Antonyuk Rostyslav S. Stoika Olha Y. Kliuchivska Nadiia R. Skorokhid Yuliia S. Kozak Nazar O. Manko Iryna I. Ivasechko Nataliya S. Finiuk Mykola V. Klishch popup.nrat_date 2025-12-23 Close