Registration Number
0225U005044,
(0123U100064)
, R & D reports
Title
Optimizing the diagnosis of clinical and pathogenetic characteristics of the COVID-19 coronavirus infection in children with comorbid pathology and treatment features
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Оптимізація діагностики клініко-патогенетичних характеристик коронавірусної інфекції COVID-19 у дітей з коморбідною патологією та особливості лікування.
Head
Pavlyshyn Halyna A., Доктор медичних наук
Registration Date
24-12-2025
Organization
Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine
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Objectification of assessment of the degree of severity and prediction of the course of the coronavirus infection COVID-19 in children with comorbid pathology based on an in-depth study of clinical and pathogenetic characteristics, indicators of cytokine status (IL-1?, IL-6, IL-8, IL-12, TNF -?, IFN-?), micronutrients (vitamins A, D, B6, B12, homocysteine, folates), hemostasis factors (Willebrand factor, factor VIII, thrombin-antithrombin complex, D-dimer, fibrinogen, activated partial thromboplastin time, prothrombin time, international normalized ratio (INR)), and optimization of treatment measures depending on accompanying pathological conditions.
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Research report: 103 p., 30 tables, 5 figures, 118 sources.
CHILDREN, COVID-19, MIS-C, GENE POLYMORPHISM, VITAMINS, INTERLEUKINS, CORTISOL, THYROID DYSFUNCTION, SEX HORMONES, HEMOSTASIS
The object of the study is the complex status of cytokine, micronutrient, endocrine, genetic, hemostatic links of the pathogenesis of SARS-CoV-2 infection in children.
Purpose of the study: objectification of the assessment of the severity and prediction of the course of COVID-19 coronavirus infection in children with comorbid pathology based on an in-depth study of clinical and pathogenetic characteristics, indicators of cytokine status, micronutrients (vitamins A, D, B6, B12, homocysteine, folate), hemostasis factors (von Willebrand factor, factor VIII, thrombin-antithrombin complex, D-dimer, fibrinogen, activated partial thromboplastin time, prothrombin time, international normalized ratio), endocrine, genetic markers and optimization of treatment measures depending on concomitant pathological conditions.
Research methods: clinical, laboratory, statistical.
The results of the research are highlighted in 12 articles published in publications indexed by the Scopus scientific-metric database, in 7 articles in professional publications of category B, and presented in 36 reports at scientific and practical conferences.
Product Description
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2025-12-24
