Registration Number
0226U000053,
(0125U000989)
, R & D reports
Title
Design, synthesis, and biological activity of new azoloazines as potential anticancer agents.
popup.stage_title
Нові 7-аміно-, 7-амідо- та 7-сульфоніламідовмісні оксазолопіримідини та їх протиракова активність.
Head
Stepan H. Pilo, д.х.н.
Registration Date
02-01-2026
Organization
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
popup.description1
Synthesis and identification of new oxazolopyrimidine and pyrazolotriazine derivatives as potential anticancer agents.
popup.description2
A series of new predictive classification and regression QSAR models were created using the OCHEM platform for the design and synthesis of 7-amino- and 7-sulfonylamide-containing oxazolopyrimidines. New substituted oxazolo[4,5-d]pyrimidines and their analogues - bicyclic condensed derivatives of thienopyrimidines, pyrrolopyrimidines, oxadiazolopyridines and oxazolopyridines - were synthesized as potential anticancer agents, the activity of which was evaluated against NCI-60 cell lines. ADMET analysis showed that all synthesized compounds meet the criteria for drug activity. Molecular docking confirmed their interaction with carbonic anhydrase XII as a possible mechanism of action, making these molecules promising candidates against CNS and lung cancer. New functionalized 2,5-diaryl-oxazolo[4,5-d]pyrimidin-7-yl-amines were synthesized and their activity against HeLa, A549, HepG2, T98G cell lines and the non-cancerous NCTC clone 929 cell line was investigated. Three compounds were found to exhibit high cytotoxicity against HeLa cells, and two of them were found to be selective for non-cancerous cells.
Product Description
popup.authors
Оleh P. Mitiukhin
Viktor V. Zhyrnov
Maryna V. Kachaieva
Serhii V. Popilnichenko
Oleksandr V. Golovchenko
Volodymyr S. Brovarets
Vasyl V. Kovalishyn
Ivan V. Semeniuta
Larysa O. Metelytsia
popup.nrat_date
2026-01-02
