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Information × Registration Number 0226U000513, (0120U105710) , R & D reports Title Biochemical mechanisms of integrated regulation of the nutritional and metabolic status of living organisms and сomprehensive biotechnological approaches for their correction popup.stage_title Біохімічні механізми інтегральної регуляції нутрієнто-метаболічного статусу живих організмів та комплексні біотехнологічні підходи їх корекції Head Kopylchuk Halyna P., Доктор біологічних наук Registration Date 12-01-2026 Organization Yuriy Fedkovych Chernivtsi National University popup.description1 establishing biochemical mechanisms of the development of organism's adaptive-compensatory reactions, integrated regulation at subcellular and cellular levels of living organisms under the conditions of a nutrient imbalance, and substantiation of the efficiency of metabolic disturbances correction by natural and synthetic compounds. popup.description2 For the first time, the biochemical mechanisms of the integral regulation of metabolic processes under conditions of nutrient imbalance and xenobiotic exposure were investigated. It was established that excessive sucrose intake and dietary protein deficiency disrupt heme-dependent, microsomal, and mitochondrial oxidative processes, leading to the development of energy maladaptation and oxidative stress, particularly in the kidneys and liver. A high-sucrose diet was shown to induce hepatic cytochrome P450 activity, whereas protein deprivation limits alternative pathways of microsomal oxidation, reflecting an adaptive metabolic rearrangement. The key role of disturbances in the prooxidant–antioxidant balance, depletion of the glutathione system, and accumulation of products of oxidative modification of biomolecules in the formation of structural and functional damage to homeostatic organs was demonstrated. It was proven that bisphenol A and pharmacological doses of retinoids enhance free-radical processes, especially in the microsomal and cytosolic fractions of the liver, while prior administration of ω-3 polyunsaturated fatty acids reduces mitochondrial oxidative imbalance. The feasibility of using vitamin-like and nutrient components for the correction of metabolic disorders was substantiated. Biotechnological approaches for the bioencapsulation of microalgae, probiotics, and carotenoid sources into live feeds (Artemia sp., Daphnia magna) were developed and optimized, ensuring high survival rates, increased nutritional value, and promising applicability in aquaculture. Product Description popup.authors Marchenko Mykhailo M. Halyna P. Kopylchuk Cheban Larysa M. Ketsa Oksana V. Liliya M. Vasina Khuda Lidiya V. Voloshchuk Oksana M. Ivanna M. Nykolaichuk Mariia Ursatyi popup.nrat_date 2026-01-12 Close