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Information × Registration Number 0226U000703, (0124U005029) , R & D reports Title Histogenesis of the components of the cardiovascular system of humans and laboratory animals under normal and experimental conditions popup.stage_title Вивчення гістогенезу компонентів серцево-судинної системи людини та лабораторних тварин в нормі та за умов експерименту Head Tverdokhlib Ihor V., Доктор медичних наук Registration Date 14-01-2026 Organization Dnipro State Medical University popup.description1 To determine the histogenetic rearrangements of the components of the cardiovascular system under normal and experimental conditions at the stages of ontogenesis of humans and experimental animals popup.description2 Ultrastructural signs of damage to the contractile apparatus of ventricular cardiomyocytes in rat offspring after chronic maternal alcohol intoxication have been determined. It has been shown that these damages are realized due to disorganization of the sarcomere structure, fragmentation and disorientation of myofibrils, significant inhibition of sarcomerogenesis, and a decrease in the content of myofibrils, which is associated with the destruction of mitochondria. The severity of changes in these structures depends on the zone and period of embryonic development. The most significant changes are due to the direct toxic effect of ethanol and are observed in the period from the 14th to the 18th day of prenatal ontogenesis Product Description popup.authors Shamelashvili Karyna Leonidivna Pavlo А. Kobeza Darya H. Marchenko popup.nrat_date 2026-01-14 Close