Registration Number
0226U000703,
(0124U005029)
, R & D reports
Title
Histogenesis of the components of the cardiovascular system of humans and laboratory animals under normal and experimental conditions
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Вивчення гістогенезу компонентів серцево-судинної системи людини та лабораторних тварин в нормі та за умов експерименту
Head
Tverdokhlib Ihor V., Доктор медичних наук
Registration Date
14-01-2026
Organization
Dnipro State Medical University
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To determine the histogenetic rearrangements of the components of the cardiovascular system under normal and experimental conditions at the stages of ontogenesis of humans and experimental animals
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Ultrastructural signs of damage to the contractile apparatus of ventricular cardiomyocytes in rat offspring after chronic maternal alcohol intoxication have been determined. It has been shown that these damages are realized due to disorganization of the sarcomere structure, fragmentation and disorientation of myofibrils, significant inhibition of sarcomerogenesis, and a decrease in the content of myofibrils, which is associated with the destruction of mitochondria. The severity of changes in these structures depends on the zone and period of embryonic development. The most significant changes are due to the direct toxic effect of ethanol and are observed in the period from the 14th to the 18th day of prenatal ontogenesis
Product Description
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Shamelashvili Karyna Leonidivna
Pavlo А. Kobeza
Darya H. Marchenko
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2026-01-14
