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Information × Registration Number 0226U001400, (0123U101850) , R & D reports Title Determination of the role of molecular genetic predictors in the early diagnosis and prognosis of malignant tumor diseases of the urinary system popup.stage_title Вивчення рівня експресії та статусу метилювання промоторних ділянок генів довгих некодуючих РНК MALAT1, HOTAIR та ANRIL Head Viktoriia Y. Harbuzova, Доктор біологічних наук Registration Date 26-01-2026 Organization Sumy State University popup.description1 The arm of the project is to create a modern tool for predicting the occurrence, assessment of the course and spread of tumors of the urinary system and the appointment of effective treatment based on the study of the relationship of single-nucleotide polymorphism variants of the long non-coding RNA genes MALAT1, HOTAIR and ANRIL, their expression levels and methylation status with the development of tumors kidneys and bladder popup.description2 During the implementation of the third stage of the project, a significant increase in the expression of the long non-coding RNAs MALAT1, HOTAIR, and ANRIL was identified in patients with tumors of the urinary system. In particular, MALAT1 expression levels were 3.2 times higher in clear cell renal cell carcinoma and 2.8 times higher in papillary bladder cancer compared with individuals without oncological diseases; carriers of the GG genotype of rs619586 exhibited a 40% higher expression level than carriers of the AA genotype. The expression of the HOTAIR gene was also significantly elevated in patients with urinary system cancers – by 4.1 times in clear cell renal cell carcinoma and by 3.3 times in papillary bladder cancer – and the presence of the minor allele of the rs4759314 polymorphism was associated with higher expression levels. Similarly, ANRIL expression exceeded control values by 1.8 times in clear cell renal cell carcinoma and by 1.5 times in papillary bladder cancer; carriers of the CC genotype of rs1333049 had a 52% higher expression level compared with carriers of the GG genotype. Mathematical modeling revealed that the development of malignant tumors of the urinary system is significantly influenced by the rs1333049 genotype of the ANRIL gene, sex, and tobacco smoking in clear cell renal cell carcinoma, as well as by the rs1333049 ANRIL genotype and body mass index in papillary bladder cancer. At the same time, the rs619586 genotype of the MALAT1 gene was identified as an independent risk factor for the development and metastasis of both malignancies and as a factor affecting overall patient survival Product Description popup.authors Viktoriia Y. Harbuzova Antonina A. Biesiedina Olha A. Obukhova Anatolii M. Romaniuk Valentyna H. Psariova Dmytro R. Hyriavenko Nadiia V. Kazban Yelizaveta A. Stroi Ruslan I. Kryvorotenko Liubov P. Lebed Hryhorii A. Sulym Iryna K. Diadiura Olha S. Rozmaita popup.nrat_date 2026-01-26 Close