Registration Number
0226U001426,
(0121U114601)
, R & D reports
Title
Reaserch title: mechanism of epigenetic disorders of the leading links of bioenergy and nitrogen metabolism in irradiated animals and their offspring
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Дослідження молекулярно-генетичних змін у структурі ферментів енергетичного обміну м’язової тканини опромінених у різних дозах тварин та їх нащадків. Встановлення ролі субстратного та окислювалюного фосфорилювання у функціонуванні м'язів опромінених тварин 01.2024 – 12.2025.
Head
Stepanov Hennadii F., к.мед.н.
Registration Date
26-01-2026
Organization
Odessa National Medical University
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Purpose of work: to study the regularities of the modifying effect of ionizing radiation on energy metabolism in the muscle tissue of irradiated animals and their offspring.
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Experimental studies of the peculiarities of energy supply of the myocardium and skeletal muscles under the influence of ionizing radiation on sexually mature rats and their offspring, which underlies the decrease in physical performance, tolerance to hypoxia and the formation of remote post-radiation effects in subsequent generations, were conducted. Particular attention was paid to the state of enzymatic systems that ensure the interaction of glycolysis, gluconeogenesis and the tricarboxylic acid cycle, as well as the mechanisms of transport of reduced equivalents in mitochondria. The results obtained allow us to consider changes in the activity of pyruvate kinase, lactate dehydrogenase, NAD and NADP-dependent malate dehydrogenases, phosphoenolpyruvate carboxykinase, as well as the lactate/pyruvate and malate/oxaloacetate ratios and the levels of ATP, ADP and AMP as a sensitive system of early biochemical markers of post-radiation disorders. The identified clear dose-dependent nature of intergenerational metabolic changes emphasizes the importance of long-term monitoring of the state of the muscular and cardiovascular systems in the offspring of individuals exposed to ionizing radiation. The complex of identified biochemical markers can be used for early detection and prediction of long-term post-radiation effects, assessment of the risk of metabolic decompensation, and justification of approaches to metabolic therapy in clinical practice.
Product Description
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Hennadii F. Stepanov
Inna R. Hridina
Yanina F. Burdina
Olha V. Storchylo
Antonina H. Vasylieva
Alina A. Kostina
Alla A. Dimova
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2026-01-26
