Registration Number
0226U001449,
(0123U100700)
, R & D reports
Title
To study the influence of post-traumatic stress associated with war on the body in people of different ages and to substantiate the methods of correction of the disorders caused by it
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Дослідити вплив на організм посттравматичного стресу, пов'язаного з війною, у людей різного віку та обґрунтувати методи корекції зумовлених ним порушень
Head
Pysaruk Anatolii V., Доктор медичних наук
Shatylo Valerii B., Доктор медичних наук
Registration Date
27-01-2026
Organization
D. F. Chebotarev Institute of Gerontology of the National academy of the medical sciences of Ukraine
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To find out the age-specific effects of war-related post-traumatic stress on the body, and to develop methods of correcting the disorders caused by it
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The aim of study was to determine the age and gender characteristics of the impact of war-related stress on the body of civilians and to substantiate methods for correcting the disorders caused by it.
193 men and women of different ages with the consequences of post-traumatic stress caused by the events of the russian-Ukrainian war were examined. The comparison groups were represented by 122 men and women examined before the war. The questionnaires PSS-10, PCL-5, STAI, BDI, ISQ, immunoenzymatic and biochemical methods, heart rate variability analysis, laser Doppler flowmetry, determination of biological age and aging rate, and the Food Frequency Questionnaire were used. The effectiveness of quercetin was studied in 65 women with stress-associated mental and somatic disorders.
During the war, women and men had increased levels of cortisol in their blood and increased sympathetic nervous system activity, indicating chronic stress. Prolonged stress led to more significant psychoemotional and sleep disorders in women than in men. In women, war stress led to the development of insulin resistance and adverse changes in carbohydrate metabolism. In elderly women and men, unlike young people, atherogenic changes in blood lipid composition increased during the war. In young men and women, prolonged stress worsened the function of the microvascular endothelium.
The frequency of post-traumatic stress disorder (PTSD) according to the PCL-5 questionnaire during the war in civilian men is three times lower than in women (p<0.05). The frequency of PTSD is highest in young women (40%) and decreases to 14% in elderly women. Women with PTSD had significantly higher levels of depression and anxiety, and more than half had significant sleep disturbances. In addition, during the war, women with PTSD had increased insulin resistance, an increased incidence of prediabetes, dyslipidemia, endothelial dysfunction, increased biological age, and accelerated aging.
Product Description
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Sinyeok Lyudmila L.
Romanenko Mariana S
Bondarenko Olena V
Antonyuk-Scheglova Ivanna A.
Iryna A. Dyba
Mechova Ludmila V
Naskalova Svetlana S
Ustymenko Alina M.
Koshel Natalya M
Ervin O. Asanov
Piven Lyubov Valentynivna
Liudmyla V. Pysaruk
Iryna V. Zaiets
Dmytro D. Osmak
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2026-01-27
