Registration Number
0226U001652,
(0123U101245)
, R & D reports
Title
Study of the effect of anticoagulants on the processes of metastasis and the effectiveness of antitumor therapy (experimental research)
popup.stage_title
Дослідження впливу антикоагулянтів прямої дії (Сулодексід, Беміпарин натрію) на метастатичну активність епідермоїдної карциноми легенів Льюїс
Head
Karatsuba Tetiana A., Кандидат біологічних наук
Registration Date
29-01-2026
Organization
Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine
popup.description1
To investigate in an experiment the effect of anticoagulants of direct and indirect action on the processes of metastasis under the conditions of the use of antitumor agents.
popup.description2
The experiments revealed a significant decrease in the metastatic activity of Lewis lung carcinoma (LLC) under the conditions of administration of sulodexide and enoxaparin. Sulodexide inhibited the formation of metastases in the lungs of mice by 63.4%, and growth by 97.3%, enoxaparin by 61.3% and 96.5%, respectively. Sulodexide and enoxaparin have a slight antitumor effect on LLC and did not significantly affect the life expectancy of animals with LLC.
The use of enoxaparin had a positive effect on animals with impaired blood coagulation activity on the background of LLC: the blood clotting time of animals administered enoxaparin increased by 6.2 times compared to animals without treatment. The administration of sulodexide did not contribute to the correction of this indicator.
The study of platelet hemostasis in experimental animals with LLC revealed a significant (2.3-fold) decrease in platelet count and a certain decrease in megakaryocytes compared to similar indicators in animals without tumors; the administration of enoxaparin and sulodexide increases the number of platelets and megakaryocytes compared to animals without treatment.
Product Description
popup.authors
Olha O. Khavych
Oleksii M. Puskov
Maksym A. Munko
Serhii V. Maksiuta
Denys O. Cherviovskyi
popup.nrat_date
2026-01-29
