Registration Number
0226U001963,
(0123U100933)
, R & D reports
Title
Optimize and implement diagnostic, therapeutic and preventive algorithms for providing medical care to patients with diabetes mellitus against the background of systemic stress-induced disorders of the endocrine and immune systems caused by military actions
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Оптимізувати та впровадити діагностичні, терапевтичні та профілактичні алгоритми надання медичної допомоги хворим з цукровим діабетом на тлі системних стрес-індукованих порушень ендокринної та імунної системи, зумовлених воєнними діями
Head
Tronko Mykola D., д.мед.н.
Registration Date
04-02-2026
Organization
State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine"
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Тo determine the pathogenetic, clinical, immunological, nutritional characteristics of stress-induced and post-COVID metabolic disorders in patients with type 1 and type 2 diabetes in order to develop methods for their correction
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The aim of the work: to determine the features of stress-induced and post-COVID metabolic and immune disorders in patients with diabetes mellitus, as well as to develop effective means for the prevention and treatment of magnesium and zinc deficiency in both patients with type 2 diabetes mellitus and in combination with subclinical hypothyroidism (SCG).
The conducted studies have shown that metabolic and immune processes are impaired in patients with COVID-19 against the background of type 2 diabetes mellitus (T2DM). Increased levels of bradykinin, AMPKα and IRS-1, activation of pAkt and a decrease in ERK1/2 were found, which indicates dysfunction of signaling pathways associated with glycemic control and the inflammatory response. In patients with acute COVID-19, the level of IL-6 increased almost threefold. In patients with diabetes mellitus who had COVID-19, a decrease in STAT3 in blood plasma was observed, which increased under the influence of insulin therapy. In blood mononuclear cells of patients after COVID-19, IKK activation and IκB reduction were noted, indicating increased inflammatory activity. In patients with newly diagnosed type 2 diabetes or disease duration ≤ 5 years, a decrease in Ca and Mg levels was noted. Se content is reduced in both prediabetes and type 2 diabetes. Type 2 diabetes on the background of subclinical hypothyroidism is accompanied by insulin resistance, dyslipidemia and a decrease in Ca, Mg, Zn and Se levels. Analysis of the intestinal microbiota showed a decrease in diversity and an imbalance in the Firmicutes/Bacteroidetes ratio in obese patients. Atherogenic dyslipidemia was detected in patients with overweight and non-proliferative diabetic retinopathy; with TG >1.7 mmol/l, the appointment of fenofibrate is recommended. Patients with the debut of type 2 diabetes after COVID-19 have been shown to have leukocyte changes and increased inflammatory activity, corrected by metformin.
Product Description
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Pushkarev Volodymyr M
Viktor I. Kravchenko
Olena I. Kovzun
Viktoria V. Popova
Valeriia L. Orlenko
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2026-02-04
