Registration Number
0226U002255,
(0125U001707)
, R & D reports
Title
Screening of new antimicrobial substances and bacteriolytic enzymes of myxobacteria for the treatment of wounds complicated by microbial infection
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Вивчення мікробіому прибережної акваторії Чорного моря, виділення ізолятів міксобактерій та дослідження їх біотехнологічного потенціалу
Head
Ivanytsia Volodymyr O., Доктор біологічних наук
Registration Date
12-02-2026
Organization
Odesa I.I. Mechnikov National University
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Search for new antimicrobial and bacteriolytic substances produced by myxobacteria, promising for the healing of wounds complicated by microbial infection.
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During the reporting stage of the research project “Screening of new antimicrobial substances and bacteriolytic enzymes of myxobacteria for the treatment of wounds complicated by microbial infection”, a comprehensive and scientifically substantiated approach was proposed and implemented, aimed at the targeted search and isolation of myxobacteria from various biotopes of the Black Sea. Myxobacteria are considered promising producers of bioactive secondary metabolites and bacteriolytic enzymes with antimicrobial activity, which is particularly relevant in the context of the increase in antibiotic resistance of pathogenic microorganisms. Molecular-ecological analysis of the microbiome of macrophytes from the coastal area of the Black Sea revealed a high taxonomic diversity of epiphytic microbial communities and confirmed the presence of myxobacteria within their composition. Based on the obtained molecular-ecological data, a targeted approach to the isolation of myxobacteria from Black Sea biotopes was applied for the first time, which significantly increased isolation efficiency and enabled the establishment of a collection of myxobacterial cultures predominantly associated with macrophytes. Investigation of the biological properties of the isolated strains confirmed their affiliation with myxobacteria and revealed features of functional specialization characteristic of a predatory lifestyle. The studied strains demonstrated bacteriolytic and antagonistic activities, mainly against Gram-positive bacteria and, to a lesser extent, against Gram-negative bacteria. Based on the overall results, promising strains were selected for further in-depth studies of their biosynthetic potential. The obtained findings provide a scientifically grounded basis for the development of new antimicrobial agents based on antimicrobial metabolites and enzymes of marine-derived myxobacteria and confirm the Black Sea as a promising source of microorganisms for biotechnological applications.
Product Description
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Volodymyr O. Ivanytsia
Mykola D. Shtenikov
Iryna V. Strashnova
Nataliia Y. Vasylieva
Mykola M. Chaban
Gennadii V. Lisiutin
Volodymyr V. Korobko
Maria A. Zaleska
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2026-02-12
