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Information × Registration Number 0226U003426, (0124U000718) , R & D reports Title Pharmacological correction of GABA-ergic system functioning disorders under conditions of diabetes. popup.stage_title Дослідження впливу ГАМК на функціонування нейронів дорзальних спинальних гангліїв здорових та діабетичних тварин Head Soloviev Anatolii I., д.мед.н. Registration Date 06-04-2026 Organization Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine popup.description1 Studying the possibilities of pharmacological correction of glucose metabolism disorders and complications in the nervous and cardiovascular systems in diabetes by influencing the GABA-ergic system popup.description2 Long-term (90 days) administration of GABA normalized the level of glycemia in the blood of fasting rats. In neurons of spinal ganglia, diabetes caused dysregulation of calcium transport. The mechanism of GABA modulation of potential-gated calcium channels in neurons of spinal ganglia was carried out through a bicuculline-insensitive pathway. GABA treatment restored serotonergic function in diabetic rats. The effect of GABA significantly improved the indicators of behavioral reactions impaired under conditions of diabetes. Consumption of GABA by diabetic rats caused a tendency to increase the level of C-peptide. GABA acted systemically on the vessels of the small and large blood circulation, restoring their morphometric and functional state, disturbed by the course of diabetes. Thus, GABA is able to exert a therapeutic effect on the course of diabetes, diabetic neuropathies and angiopathies in rats. Product Description popup.authors Nataliia V. Dobrelia Oleksandr V. Parshykov Lyudmyla V. Boitsova Іryna V. Іvanova Ihor L. Monchak Anatoliy I. Soloviyov Vadym H. Sydorenko popup.nrat_date 2026-04-06 Close