Registration Number
0226U003426,
(0124U000718)
, R & D reports
Title
Pharmacological correction of GABA-ergic system functioning disorders under conditions of diabetes.
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Дослідження впливу ГАМК на функціонування нейронів дорзальних спинальних гангліїв здорових та діабетичних тварин
Head
Soloviev Anatolii I., д.мед.н.
Registration Date
06-04-2026
Organization
Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine
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Studying the possibilities of pharmacological correction of glucose metabolism disorders and complications in the nervous and cardiovascular systems in diabetes by influencing the GABA-ergic system
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Long-term (90 days) administration of GABA normalized the level of glycemia in the blood of fasting rats. In neurons of spinal ganglia, diabetes caused dysregulation of calcium transport. The mechanism of GABA modulation of potential-gated calcium channels in neurons of spinal ganglia was carried out through a bicuculline-insensitive pathway. GABA treatment restored serotonergic function in diabetic rats. The effect of GABA significantly improved the indicators of behavioral reactions impaired under conditions of diabetes. Consumption of GABA by diabetic rats caused a tendency to increase the level of C-peptide. GABA acted systemically on the vessels of the small and large blood circulation, restoring their morphometric and functional state, disturbed by the course of diabetes. Thus, GABA is able to exert a therapeutic effect on the course of diabetes, diabetic neuropathies and angiopathies in rats.
Product Description
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Nataliia V. Dobrelia
Oleksandr V. Parshykov
Lyudmyla V. Boitsova
Іryna V. Іvanova
Ihor L. Monchak
Anatoliy I. Soloviyov
Vadym H. Sydorenko
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2026-04-06
