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Information × Registration Number 0226U003607, (0123U102515) , R & D reports Title Development of new materials based on metals (Ag, Au) nanoparticles and titanium dioxide for sulfur-containing amino acids and peptides sensors popup.stage_title Розроблення нових матеріалів на основі наночастинок металів (Ag, Au) і діоксиду титану для сенсорів на сіркувмісні амінокислоти та пептиди Head Petro A. Manoryk, Доктор хімічних наук Registration Date 22-04-2026 Organization L. V. Pisarzhevskii Institute Of Physical Chemistry of The National Academy of Sciences of Ukraine popup.description1 obtaining of metal nanoparticles (Ag, Au) stabilized by amino acids or peptides with certain chemical composition and dispersion, which, in combination with a titanium oxide component characterized by a certain phase and chemical composition, morphology, textural characteristics, can exhibit sensory properties in relation to sulfur-containing amino acids and peptides . popup.description2 By varying the reaction mixturequalitative and quantitative composition, the components molar ratio, pH, and synthesis conditions, α-amino acid-stabilized spheroidal morphology silver nanoparticles NPs(Ag) with average sizes ~ 15 nm and a narrow size distribution were obtained. The influence of reaction mixture qualitative and quantitative composition, pH ​​on the average sizes and distribution of the α-amino acid-stabilized NPs(Ag) was investigated. It was shown that for preparation of NPs(Ag) colloidal solutions with an average diameter ≤15 nm and a narrow size distribution, necessary prerequisite is the creation of conditions which one complex particle AgL2-, as a precursor for NPs(Ag), dominates in the solution (≥ 95%). It was found that glycine, as well as most of the amino acids studied, such conditions are Ag/Gly ≥20 at pH ≥10. It was shown that the most effective ligands for obtaining small spheroidal NPs(Ag) with a narrow size distribution are glycine, tryptophan, tyrosine. It was found that under the same conditions, with an increase in the content of the reducing agent in the solution, the rate constants of NPs(Ag) formation increase, average sizes decrease, and size distribution improves. It was shown that an increase in pH in the system, which leads to a shift the equilibria and, accordingly, to a change in the precursors from which the nanoparticles are reduced, also causes formation processes acceleration. It is shown that the interaction of colloidal solutions of NPs(Ag) and NPs(Au) with sulfur-containing amino acids and peptides (analytes) leads to SPR band position, shape, intensity changes, and the magnitude of these changes depends on both the analyte nature and its concentration. The plasmon characteristics linear dependences on the analyte concentration obtained for a numbur systems make them suitable for determining the content of cysteine, glutathione, thiamine pyrophosphate in the solution in the wide concentration range (10-5-10-3 M). Product Description popup.authors Volodymyr M. Grebennikov Oleksandr Y. Tverskov Oleksandr V. Shuljenko Nataliia I. Romanovska popup.nrat_date 2026-04-22 Close