Registration Number
0226U004335,
(0124U004303)
, R & D reports
Title
Innovative approaches to the analysis and correction of the microbiome in the diagnosis, prevention and treatment of post-traumatic stress disorders
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Узагальнення одержаних результатів, розробка протоколів персоніфікованої діагностики, профілактики та лікування ПТСР
Head
Boyko Nadiia V., д.б.н.
Registration Date
07-08-2026
Organization
Uzhhorod National University State Higher Educational Institution
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The aim of the work is the development and implementation of innovative biotechnological approaches related to the human microbiome to solve the diagnostic and therapeutic component of the most common challenge of war - post-traumatic stress disorders of military personnel and the civilian population of Ukraine.
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The project is devoted to the development of innovative biotechnological approaches to the diagnosis, prevention and treatment of post-traumatic stress disorder (PTSD) based on the analysis of the human microbiome. Using next-generation sequencing (NGS), the gut microbiome of three cohorts — military personnel with PTSD, military personnel without PTSD, and internally displaced persons — was studied, and from more than 200 detected bacterial species, 17 biomarker species were selected that statistically significantly differentiate the study groups. Based on the selected markers, predictive mathematical models for PTSD risk assessment with an integral microbiome-based risk score were developed and validated, along with personalised protocols for diagnosis, prevention and treatment and an information system for biotherapy selection. The development of a rapid test system based on the polymerase chain reaction (PCR) was initiated under a signed memorandum of cooperation, and pilot samples of probiotic preparations and functional foods with psychobiotic action were produced. The results are of practical value for the military medical service, the rehabilitation of veterans and internally displaced persons, and the development of the domestic biopharmaceutical industry.
Product Description
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Drobnych Volodymyr H.
Nadiya V. Boyko
Nataliia I. Korol
Lesia S. Yusko
Mynia Oleksandr Yo.
Oleksandra V. Pallah
Fedorka Pavlo P.
Burmei Svitlana A.
Lypei Ivan M.
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2026-08-07
