Registration Number
0226U004602,
(0125U003284)
, R & D reports
Title
Fine structural alterations of the neurogenic niche in Alzheimer’s disease
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Структурні взаємодії між нейральними стовбуровими, астроцитами та мікроглією при хворобі Альцгеймера
Head
Tsupykov Oleh M., Доктор медичних наук
Registration Date
08-10-2026
Organization
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
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This project aims to explore the intricate morphological interactions between adult neural stem cells (aNSC) and their neurogenic niche, specifically investigating the alterations in Alzheimer's disease (AD). Focusing on two key questions, the study seeks to understand changes in structural interactions between aNSC, astrocytes, and microglia in AD using a common mouse model. Additionally, the project examines the impact of vascular amyloidosis on aNSC perivascular processes, exploring potential dysregulation of proliferation in the context of AD. By employing advanced microscopy techniques, this research aims to uncover crucial insights into the pathogenesis of AD, offering a foundation for understanding aNSC regulation within the neurogenic niche.
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The aim of this project is to investigate the complex structural interactions between adult neural stem cells and their neurogenic niche, particularly in Alzheimer's disease. During the second stage of the project, structural changes in the interactions among neural stem cells (NSCs), astrocytes, and microglia were investigated in Nestin/GFPxAPP PS1 transgenic mice (an Alzheimer's disease model) using a JEM-100CX transmission electron microscope (JEOL, Japan). The obtained data will serve as a morphological foundation for further determining the relationship among NSCs, blood vessels, and vascular amyloid plaques using electron microscopy during the third stage of the project.
Product Description
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Halyna H. Skybo
Oleh M. Tsupykov
Iryna V. Lushnikova
Serhii O. Shchepanskyi
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2026-10-08
