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Information × Registration Number 0305U003506, 0103U004272 , R & D reports Title Heme metabolism regulation at NO radical level modulation under oxidative stress. popup.stage_title Дослідження регуляції ключових ферментів гему та гемопротеїнів NO і його похідними в різних органах щурів в умовах ексидативного стресу, спричиненого введенням солей важких металів Head Kaliman P.A., Registration Date 25-04-2005 Organization Kharkov national university named after V.N. Karazin popup.description2 The aim of this study was to investigate the role of NO-radicals in the regulation of heme and hemoprotein metabolism under the oxidative stress. Subject of this investigation - heme metabolism and some parameters of antioxi-dative-prooxidative status of rat's liver, kidney spleen and blood serum under the oxi-dative stress. The heme oxygenase, tryptophan-2,3-dioxygenase, d- aminolevulinate synthase, lactate dehydrogenase activities, MDA content, the level of spontaneous LPO and re-duce glutathione content in liver, kidney and spleen of rats at different times after CdCl2 administration, co-administration of L-arginine or sodium nitroprusside and CdCl2 was studied. The Wistar rats were used in the work. Treatment with metal salt caused the hemolysis products accumulation in blood serum and their further transport into the liver and kidney. Pretreatment by L-arginine prevents damage of differen tissues, that was confirmed by decreasing of lactate dehydrogenase activity in blood serum at 24 h after CdCl2 administration. Sodium nitroprusside and L-arginine block the decreasing as well as increasing of d- aminolevulinate synthase activity, caused by CdCl2 admini-stration. As result of these was prevented the free heme accumulation in the liver in later period of CdCl2 validity. Product Description popup.authors popup.nrat_date 2020-04-02 Close