Search academic texts

Information × Registration Number 0306U001290, 0104U003631 , R & D reports Title To study new program treatment of acute leukemia and myelodysplastic syndromes in patients who suffered from Chornobyl accident to take in account their molecular-genetic date and multiple drug resistance popup.stage_title Продовжити вивчення особливостей гострих лейкемій та мієлодиспластичних синдромів. Виділити діагностичні та прогностичні критерії з урахуванням цитогенетичних та молекулярно-генетичних порушень у хворих на гострі лейкемії та мієлодиспластичні синдроми для прогнозування результатів лікування Head Bebeshko V.G., Доктор медичних наук Registration Date 20-02-2006 Organization Research Centre for Radiation Medicine popup.description2 The object of the study: patients with acute leukemias and myelodysplastic syndromes who suffered from Chornobyl accident. The aim of the study to elaborate the differential approaches to the acute leukemias and myelodysplastic syndromes treatment in patients who suffered from Chornobyl accident according to their molecular-genetic date and multiple drug resistance. The clinical, morphological, histological, immunological, cytogenetical, molecular and mathematical methods have been used. 63 patients were examined. Among them 39 patients suffered from Chornobyl accident - 35 acute leukemia patients (15 ALL and 20 AML) and 4 - MDS one. The oposite group included 24 patients (12 ALL , 8 AML and 4 MDS one) not exposed. For radioassociation AL is more frequent encreased in the blast cells in periferal blood among clean-up workers (P<0.05) vs not exposed persons. For AL and MDS patients is tipical qualitive changes in peripheral blood and bone marrow cells. The more typical sings for radioassociation AML are: aged uper 35, infection complications, not eligable to be treated by intensive chemotherapy. BCR/ABL translocation in radioassociation AML is poore prognostic factor. The gene expression of the Bcl-2 and Bcl-XL may be reason of the drug resistens. .Presence of different alterations in kariotype in MDS patients could led to AML transformation. Product Description popup.authors popup.nrat_date 2020-04-02 Close