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Information × Registration Number 0309U000871, 0107U003073 , R & D reports Title Design of new technologies to diagnose development and progressing of an arterial hypertension popup.stage_title Вивчення особливостей структурного поліморфізму генів системи РАС у хворих на АГ. Встановлення взаємозв'язку характеру поразки органів-мішеней у хворих АГ зі структурним поліморфізмом генів системи РАС. Head Dzyak G, Registration Date 04-01-2010 Organization Dniepropetrovsk State Medical Akademy popup.description2 The aim of phase: determine structural polymorphism of genes of races and explore the impact of gene-gene interaction between I / D polymorphism of ACE gene polymorphism and A1166S gene AT1 receptors to angiotensin II in the nature of the defeat of target organs in patients with AH. Methods: daily blood pressure monitoring, echocardiography, dopler-echocardiography, molecular genetic studies of gene polymorphisms of races. Equipment: device AVRM-04 to daily monitoring of AB (the company "Meditech", Hungary), ultrasonic apparatus "Ultramark 9" NDI (Japan). Theoretical and practical results: 1. For the first time in patients with GH HLSH particular set of clinical characteristics hronobiolohichnyh AT and structural and functional state of the heart, found gender differences depending A1166S polymorphism of AT1 receptor gene to AII. 2. Influence of gene-gene interaction between structural polymorphism of genes of Ras: I / D polymorphism of ACE gene polymorphism and A1166S gene AT1 receptors to angiotensin II in the nature of the defeat of target organs in patients with GH. 3. Found that homozygous state Allele C in comparison with other genotypes AT1 receptor gene for angiotensin II associated with a greater value IMMLSH, concentric type remodelyuvannya infarction in conjunction with violations of left ventricular diastolic function, which makes more difficult the course of GH in patients with genotype CC. 4. Found a negative contribution to disease progression, growth HLSH, forming concentric type remodelyuvannya presence of infarction in patients with GH genotypes, especially in homozihotnomu condition, D allele ACE gene and AT1 receptor gene 1166S to angiotensin II. 5. Established the feasibility determination in patients with GH gene genotype of ACE gene and AT1 receptors to angiotensin II to determine the severity of disease prognosis and development HLSH, to allocate patients among high-risk groups, the appointment of effective treatment and implementation of preventive maintenance. Novelty: improvement in practice, the stratification of risk of complications and optimization tactics of individual patients for primary and secondary prevention of cardiovascular complications based on the identification of clinical and genetic markers failure of target organs in patients with AH, highlighting high-risk groups and develop the most effective means of treatment in patients with AH. Introduction: Antihipertenzyvnyy Center 11th City Hospital, Dnepropetrovsk, Road Hospital for centuries .. Dnepropetrovsk. Scope of implementation: cardiology and therapy in outpatient and inpatient level. Product Description popup.authors Алексєєнко Зоя Константинівна Дзяк Георгій Вікторовіч Колеснік Тетяна Володимирівна Останіна Тетяна Георгіївна popup.nrat_date 2020-04-02 Close