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Information × Registration Number 0311U003269, 0109U000438 , R & D reports Title The development of the method of combined treatment of patients with invasive bladder cancer by optimizing the methods of surgery depending on the effectiveness of neoadjuvant chemotherapy popup.stage_title Науково обґрунтувати покази до органозберігаючих та органовиносних оперативних втручань у хворих на інвазивний рак сечового міхура в залежності від стадії процесу, анатомо-функціональних змін сечовивідних шляхів та ефективності неод'ювантної хіміотерапії Head Eduard Stakhovsky, Registration Date 25-02-2011 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Research object - 57 patients with the urinary bladder invasive cancer diagnosis. Research (work) purpose - to improve the effectiveness of multimodality therapy and the quality of patients life with the diagnosis of the urinary bladder invasive cancer by means of using neo-adjuvant chemotherapy and research of its influence on anatomical - histological structure of the urinary bladder tumour and also the improvement of surgical (tactics) of treatment. Research methods: clinical, laboratory, X-ray - radiological, endoscopic, instrumental, pathomorphological, statistical. It has been established that the implementation of neo-adjuvant poly-chemotherapy during the treatment of patients with the invasive urinary bladder cancer diagnosis allowed to get complete recovery in 9,1 % cases, and in 50 % - partial regression of tumorous process. Analysis of the treatment results which has been conducted among the patients with the diagnosis of the invasive cancer of urinary bladder has exposed a directly proportional relation between the level of tumour differentiation (G) and the level of tumour regression under the effect of the neo-adjuvant poly-chemotherapy (G1 - 87,5 ± 17,7 %; G2 - 52,7 ± 29,3%; G3 - 23,1 ± 43,4% according to RECIST criteria). Conducting of the neo-adjuvant poly-chemotherapy among the patients who suffer the urinary bladder invasive cancer allowed to improve or normalize kidneys function and uro-dynamics of the upper urinary tracts in 40%. An authentic prostate decrease in size, improvement of urination act and quality of life in general were detected as a result after the conducting of the neo-adjuvant poly-chemotherapy among the patients with invasive CUB (cancer of the urinary bladder). It has been found out that the neo-adjuvant poly-chemotherapy causes a regression of the invasive CUB in 59,1 % and decrease of invasion depth in 54,5 % which gives the possibility to conduct a surgical intervention which would be of "organs preserving" type and thereby get the patient's quality of life much more better. It was discovered that there is a direct dependence of the increase of apoptosis index from the tumour regression level under the effect of the neo-adjuvant poly-chemotherapy according RECIST (р < 0,05) criteria which allows to recommend the usage of imuno-fluorescent investigation with the using of confocal microscopy as an effectiveness of poly-chemotherapy prognosis criteria to among the invasive CUB patients. It was indicated that the injection of dexketoprophen 20-22 hours before the surgery procedure helps to get a clear postsurgical anesthesia as compared to the using of analgesics on an early preoperative stage (р=0,001). Besides, it is proved that the usage of dexketoprophen 20-22 hours before the beginning of the surgery leads to the decrease of Е2 prostaglandines level in plasma and CSF (Cerebro - Spinal Fluid) as compared to the patients who took placebo and ketorolak (р=0,0009 and 0,0002), which signifies about a decrease of central sensitization and pain chronization in a further postsurgical period. Product Description popup.authors Вітрук Юрій Васильович Войленко Олег Анатолійович Вукалович Петро Семенович Гаврилюк Оксана Миколаївна Климчук Людмила В'ячеславівна Кононенко Олексій Анатолійович Лесной Іван Іванович Лялькін Сергій Анатолійович Новосад Юрій Ігоревич Яцина Олександр Іванович popup.nrat_date 2020-04-02 Close