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Information × Registration Number 0318U004255, 0118U005061 , R & D reports Title Synthesis and optimization of polyhalogen-containing carboxyamidines - potential antiepileptic agents. popup.stage_title Синтез полігалогеновмісних карбоксиамідинів - потенційних антиепілептичних агентів. Розробка методик синтезу полігалогеновмісних карбоксиамідинів - потенційних антиепілептичних агентів. Head Boyko Oleksandr, Registration Date 18-12-2018 Organization Taras Shevchenko Kiev University popup.description2 Object of research: Organic heterocyclic compounds as potential medicinal products. Purpose: development of innovative means of pharmacological influence on the pathological synchronization of neural networks of the brain, which underlie epileptic seizures of different etiologies. With the use of complex modeling of regulators, taking into account the structure of the potential target, and the task for the synthesis of the simulated compounds, three new compounds - inhibitors of proton-sensitive channels of ASICs, namely: 2 dichloric baryadecarboxydiimines and fluorine-containing carboxydimin, were synthesized. Product Description popup.authors Бойко Олександр Миколайович Наумчик Василь Степанович popup.nrat_date 2020-04-02 Close