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0408U004910,
к.фарм.н.
21-11-2008
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Pharmaceutical experimental study for Lipophilic of Soya extract and GEXAFAN ointment
Hassan Ali Dib Hijazi,
popup.head Maloshtan Ludmila Mikolaevna
popup.opponent Дроговоз Світлана Мефодіївна
popup.opponent Чекман Іван Сергійович
Дисертація присвячена фармакологічному вивченню ліпофільного екстракту з сої (ЛЕС) та мазі Гексафен, розробленої на основі ЛЕС.Встановлена виразна протизапальна дія ЛЕС на моделях карагенінового, зимозанового та формалінового запалення. Доведено, що ЛЕС у дозі 4 мг/кг виявив судиннозміцнюючу, мембраностабілізувальну та антиоксидантну дію. Експериментально доведено, що мазь Гексафен, до складу якої входить ЛЕС, чинить значний терапевтичний вплив на стан ранових процесів шкіри різного генезу (термічного, алергічного, опікового, різаного та інш.) та перевершує за виразністю терапевтичний ефект препарату порівняння мазь Вундехіл у середньому у 2 рази. Нова комбінована мазь Гексафен за результатами токсикологічних досліджень є відносно нетоксичною, не виявляє місцево-подразнюючої, алергізуючої та шкірорезорбтивної дії.
2008-11-21
2020-04-04
Updated: 2025-12-07
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